Benzylisoquinoline alkaloids (BIAs) are among the most important plant secondary metabolites, in that they include a number of biologically active substances widely employed as pharmaceuticals. Isolation of BIAs from their natural sources is an expensive and time-consuming procedure as they accumulate in very low levels in plant. Moreover, total synthesis is challenging due to the presence of stereogenic centers. In view of these considerations, green and scalable methods for BIA synthesis using fully enzymatic approaches are getting more and more attention. The aim of this paper is to review fully enzymatic strategies for producing the benzylisoquinoline central precursor, (S)-norcoclaurine and its derivatives. Specifically, we will detail the current status of synthesis of BIAs in microbial hosts as well as using isolated and recombinant enzymes.

Green routes for the production of enantiopure benzylisoquinoline alkaloids / Ghirga, Francesca; Bonamore, Alessandra; Calisti, Lorenzo; D'Acquarica, Ilaria; Mori, Mattia; Botta, Bruno; Boffi, Alberto; Macone, Alberto. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 18:11(2017). [10.3390/ijms18112464]

Green routes for the production of enantiopure benzylisoquinoline alkaloids

Ghirga, Francesca;Bonamore, Alessandra
;
Calisti, Lorenzo;D'acquarica, Ilaria
;
Mori, Mattia;Botta, Bruno;Boffi, Alberto;Macone, Alberto
2017

Abstract

Benzylisoquinoline alkaloids (BIAs) are among the most important plant secondary metabolites, in that they include a number of biologically active substances widely employed as pharmaceuticals. Isolation of BIAs from their natural sources is an expensive and time-consuming procedure as they accumulate in very low levels in plant. Moreover, total synthesis is challenging due to the presence of stereogenic centers. In view of these considerations, green and scalable methods for BIA synthesis using fully enzymatic approaches are getting more and more attention. The aim of this paper is to review fully enzymatic strategies for producing the benzylisoquinoline central precursor, (S)-norcoclaurine and its derivatives. Specifically, we will detail the current status of synthesis of BIAs in microbial hosts as well as using isolated and recombinant enzymes.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1021474
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