To improve the well-being of food-producing animals, the use of anti-inflammatory drugs (AIDs) for pain management has become common practise in cattle breeding. Because of the frequency of treatment and inadequate withdrawal times, it is probable that residues of these pharmaceuticals will be found in human food, such as milk, meat and eggs. The two classes of anti-inflammatories most used in veterinary medicine are corticosteroids and non-steroidal AIDs (NSAIDs); the potentially adverse effects of these compounds has induced the governing authorities to regulate their residue levels in different animal-food products. Because of the chemical properties of AIDs, liquid chromatography (LC) coupled to mass spectrometry (MS) is the technique of choice for performing multi-residue analysis in complex matrices and confirming their identity. This article reviews the current status of applying LC-MS in analyzing AIDs. We address instrumental aspects (e.g., ionization sources and analyzers) as well as extraction procedures, the complexity of which is linked to the sensitivity and the selectivity of LC-MS and to matrix effects. © 2007 Elsevier Ltd. All rights reserved.

LC-MS methods for analyzing anti-inflammatory drugs in animal-food products / Gentili, Alessandra. - In: TRAC. TRENDS IN ANALYTICAL CHEMISTRY. - ISSN 0165-9936. - STAMPA. - 26:6(2007), pp. 595-608. [10.1016/j.trac.2007.01.013]

LC-MS methods for analyzing anti-inflammatory drugs in animal-food products

GENTILI, Alessandra
2007

Abstract

To improve the well-being of food-producing animals, the use of anti-inflammatory drugs (AIDs) for pain management has become common practise in cattle breeding. Because of the frequency of treatment and inadequate withdrawal times, it is probable that residues of these pharmaceuticals will be found in human food, such as milk, meat and eggs. The two classes of anti-inflammatories most used in veterinary medicine are corticosteroids and non-steroidal AIDs (NSAIDs); the potentially adverse effects of these compounds has induced the governing authorities to regulate their residue levels in different animal-food products. Because of the chemical properties of AIDs, liquid chromatography (LC) coupled to mass spectrometry (MS) is the technique of choice for performing multi-residue analysis in complex matrices and confirming their identity. This article reviews the current status of applying LC-MS in analyzing AIDs. We address instrumental aspects (e.g., ionization sources and analyzers) as well as extraction procedures, the complexity of which is linked to the sensitivity and the selectivity of LC-MS and to matrix effects. © 2007 Elsevier Ltd. All rights reserved.
2007
aid; anti-inflammatory drug; anti-inflammatory drugs; chromatographic technique; corticosteroid; corticosteroids; lc-ms; liquid chromatography; mass spectrometry; meat; milk; non-steroidal anti-inflammatory drug; non-steroidal anti-inflammatory drugs; nsaid
01 Pubblicazione su rivista::01a Articolo in rivista
LC-MS methods for analyzing anti-inflammatory drugs in animal-food products / Gentili, Alessandra. - In: TRAC. TRENDS IN ANALYTICAL CHEMISTRY. - ISSN 0165-9936. - STAMPA. - 26:6(2007), pp. 595-608. [10.1016/j.trac.2007.01.013]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/102098
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 43
social impact