Iron deposition in the brain normally increase with age, but its accumulation in certain regions is ob- served in a number of neurodegenerative diseases in- cluding Parkinson’s disease (PD) and other parkinson- isms. Whether iron overload leads to dopaminergic neu- ronal death in the SN of PD patients or is instead sim- ply a by-product of the neurodegenerative progression is still yet to be ascertained. Magnetic resonance imaging (MRI) is a non-invasive method to assess brain iron content in PD patients. In PD, accurate radiologic visu- alization of basal ganglia is required. Deep gray matter nuclei are well presented in T2- and T2*-weighted im- ages. T2*-weighted gradient-echo (GRE) is widely used to assess calcifications and also for iron detection. On the other hand, new methods specifically designed for detecting iron-induced susceptibility differences can be further improved by sequences like susceptibility- weighted imaging (SWI). In the present review, we aim to summarize the available data on brain iron de- position in PD.

Iron metabolism and its detection through MRI in parkinsonian disorders: a systematic review / Pietracupa, Sara; Martin-bastida, Antonio; Piccini, Paola. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - (2017), pp. 1-7. [10.1007/s10072-017-3099-y]

Iron metabolism and its detection through MRI in parkinsonian disorders: a systematic review

Pietracupa, Sara
;
2017

Abstract

Iron deposition in the brain normally increase with age, but its accumulation in certain regions is ob- served in a number of neurodegenerative diseases in- cluding Parkinson’s disease (PD) and other parkinson- isms. Whether iron overload leads to dopaminergic neu- ronal death in the SN of PD patients or is instead sim- ply a by-product of the neurodegenerative progression is still yet to be ascertained. Magnetic resonance imaging (MRI) is a non-invasive method to assess brain iron content in PD patients. In PD, accurate radiologic visu- alization of basal ganglia is required. Deep gray matter nuclei are well presented in T2- and T2*-weighted im- ages. T2*-weighted gradient-echo (GRE) is widely used to assess calcifications and also for iron detection. On the other hand, new methods specifically designed for detecting iron-induced susceptibility differences can be further improved by sequences like susceptibility- weighted imaging (SWI). In the present review, we aim to summarize the available data on brain iron de- position in PD.
2017
Iron; Magnetic resonance imaging; Parkinsonian disorders; Parkinson’s disease; 2708; Neurology (clinical); Psychiatry and Mental Health
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Iron metabolism and its detection through MRI in parkinsonian disorders: a systematic review / Pietracupa, Sara; Martin-bastida, Antonio; Piccini, Paola. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - (2017), pp. 1-7. [10.1007/s10072-017-3099-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1020832
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