Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion: The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma.

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites / Mezi, S; Chiappetta, C; Carletti, R; Nardini, A; Cortesi, E; Orsi, E; Piesco, G; Di Gioia, C.. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 39:9(2017), pp. 1806-1818. [10.1002/hed.24838]

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

Mezi S
Primo
;
Chiappetta C
Secondo
;
Carletti R;Cortesi E;Orsi E;Piesco G
Penultimo
;
Di Gioia C.
Ultimo
2017

Abstract

Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion: The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma.
E-chaderin; EMT; laryngeal carcinoma; N-chaderin; beta-catenin
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites / Mezi, S; Chiappetta, C; Carletti, R; Nardini, A; Cortesi, E; Orsi, E; Piesco, G; Di Gioia, C.. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 39:9(2017), pp. 1806-1818. [10.1002/hed.24838]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1020315
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