Introduction: Small intestinal (SI) neuroendocrine tumors (NETs) are relatively rare tumors. Due to the lack of symptom or specific symptoms, SI-NETs are often diagnosed at an advanced stage, making therapy challenging. The management of patients with advanced stage SI-NETS requires a multidisciplinary approach that combines surgical and medical treatment including novel targeted molecular therapies. Areas covered: This article summarizes current strategies for the medical treatment of SI-NETS. Expert commentary: The treatment plan of advanced-stage SI-NETs should be tailored in a case-bycase manner with the adoption of a multidisciplinary approach that combines different treatment options, including biological targeted therapies. In particular, we believe that the identification of the optimal treatment sequence(s), correct treatment timing and the selection of patients eligible to different treatments need specific investigation in controlled clinical trials.

Update on medical treatment of small intestinal neuroendocrine tumors / Pusceddu, Sara; Femia, Daniela; Lo Russo, Giuseppe; Ortolani, Silvia; Milione, Massimo; Maccauro, Marco; Vernieri, Claudio; Prinzi, Natalie; Concas, Laura; Leuzzi, Livia; De Braud, Filippo; Buzzoni, Roberto. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 16:9(2016), pp. 969-976. [10.1080/14737140.2016.1207534]

Update on medical treatment of small intestinal neuroendocrine tumors

Lo Russo, Giuseppe
;
Ortolani, Silvia
;
MILIONE, Massimo
;
Prinzi, Natalie
;
2016

Abstract

Introduction: Small intestinal (SI) neuroendocrine tumors (NETs) are relatively rare tumors. Due to the lack of symptom or specific symptoms, SI-NETs are often diagnosed at an advanced stage, making therapy challenging. The management of patients with advanced stage SI-NETS requires a multidisciplinary approach that combines surgical and medical treatment including novel targeted molecular therapies. Areas covered: This article summarizes current strategies for the medical treatment of SI-NETS. Expert commentary: The treatment plan of advanced-stage SI-NETs should be tailored in a case-bycase manner with the adoption of a multidisciplinary approach that combines different treatment options, including biological targeted therapies. In particular, we believe that the identification of the optimal treatment sequence(s), correct treatment timing and the selection of patients eligible to different treatments need specific investigation in controlled clinical trials.
2016
Chemotherapy; interferon; Intestinal neoplasms; molecular targeted therapy; neoplasm staging; neuroendocrine tumors; peptide receptor radionuclide therapy; prognosis; somatostatin analogues; Antineoplastic Agents; Combined Modality Therapy; Humans; Intestinal Neoplasms; Intestine, Small; Molecular Targeted Therapy; Neoplasm Staging; Neuroendocrine Tumors; Patient Selection; Oncology; Pharmacology (medical)
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Update on medical treatment of small intestinal neuroendocrine tumors / Pusceddu, Sara; Femia, Daniela; Lo Russo, Giuseppe; Ortolani, Silvia; Milione, Massimo; Maccauro, Marco; Vernieri, Claudio; Prinzi, Natalie; Concas, Laura; Leuzzi, Livia; De Braud, Filippo; Buzzoni, Roberto. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 16:9(2016), pp. 969-976. [10.1080/14737140.2016.1207534]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1018475
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