Nano-systems, often used in biomedical applications for the treatment of a broad category of illnesses, represent one of the nanomedicine approaches recently proposed to target specific drugs only in the region where the disease has been developed. Recently the use of this technique has been proposed with electropulsation, hence taking advantage of the enhanced permeabilization of the cell membrane and simultaneously control the release of the encapsulated drug by the nano-system. In this work, we focus our attention on the study of liposomes nano-systems controlled by the nanosecond pulses electric fields through a microdosimetric approach. The aim is to analyse the electric field necessary to porate a non-uniform distribution of 400 nm liposomes. The work has been carried out by randomly placing 30 liposomes between two electrodes with the application of a 10 nano-second electric field pulse
Numerical estimation of a 10 nanosecond pulse effects on non-uniformly distributed liposomes / Della Valle, Elena; Apollonio, Francesca; Liberti, Micaela; Denzi, Agnese; Mir, Lluis M.. - ELETTRONICO. - (2017), pp. 1-3. (Intervento presentato al convegno 14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design, SMACD 2017 tenutosi a Atahotel Naxos Beach Conference Centre, Via Recanati, ita nel 2017) [10.1109/SMACD.2017.7981605].
Numerical estimation of a 10 nanosecond pulse effects on non-uniformly distributed liposomes
Della Valle, Elena;Apollonio, Francesca;Liberti, Micaela;Denzi, Agnese;
2017
Abstract
Nano-systems, often used in biomedical applications for the treatment of a broad category of illnesses, represent one of the nanomedicine approaches recently proposed to target specific drugs only in the region where the disease has been developed. Recently the use of this technique has been proposed with electropulsation, hence taking advantage of the enhanced permeabilization of the cell membrane and simultaneously control the release of the encapsulated drug by the nano-system. In this work, we focus our attention on the study of liposomes nano-systems controlled by the nanosecond pulses electric fields through a microdosimetric approach. The aim is to analyse the electric field necessary to porate a non-uniform distribution of 400 nm liposomes. The work has been carried out by randomly placing 30 liposomes between two electrodes with the application of a 10 nano-second electric field pulseFile | Dimensione | Formato | |
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