Obesity is a severe public health problem worldwide, leading to an insulin-resistant state in liver, adipose, and muscle tissue, representing a risk factor for type 2 diabetes mellitus, cardiovascular diseases, and cancer. We have shown that abdominal obesity is associated with homeostasis derangement, linked to several hormonal and paracrine factors. Data regarding potential link between GH/IGF1 axis, bone mineral density, and inflammation in obesity are lacking. Thus, aim of this study was to evaluate correlation among IGF-1, BMD, and inflammation in obese individuals.
Insulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects / Fornari, Rachele; Marocco, Chiara; Francomano, Davide; Fittipaldi, Simona; Lubrano, Carla; Bimonte, VIVIANA MARIA; Donini, Lorenzo Maria; Nicolai, Emanuele; Aversa, Antonio; Lenzi, Andrea; Greco, Emanuela A; Migliaccio, Silvia. - In: EATING AND WEIGHT DISORDERS. - ISSN 1124-4909. - ELETTRONICO. - (2017). [10.1007/s40519-017-0362-4]
Insulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects
FORNARI, RACHELE;MAROCCO, CHIARA;FRANCOMANO, DAVIDE;FITTIPALDI, SIMONA;LUBRANO, Carla;BIMONTE, VIVIANA MARIA;DONINI, Lorenzo Maria;LENZI, Andrea;
2017
Abstract
Obesity is a severe public health problem worldwide, leading to an insulin-resistant state in liver, adipose, and muscle tissue, representing a risk factor for type 2 diabetes mellitus, cardiovascular diseases, and cancer. We have shown that abdominal obesity is associated with homeostasis derangement, linked to several hormonal and paracrine factors. Data regarding potential link between GH/IGF1 axis, bone mineral density, and inflammation in obesity are lacking. Thus, aim of this study was to evaluate correlation among IGF-1, BMD, and inflammation in obese individuals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
