Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.
HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature / Carrone, Angela; Riganelli, Lucia; Savone, Delia; Casorelli, Assunta; Merlino, Lucia; Pecorini, Francesco; Pecorella, Irene; Mancino, Pasquale; Piccioni, Maria Grazia; Benedetti Panici, Pierluigi. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 103:6(2017), pp. 511-515. [10.5301/tj.5000642]
HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature
Carrone, AngelaPrimo
;Riganelli, LuciaSecondo
;Savone, Delia
;Casorelli, Assunta;Merlino, Lucia;Pecorini, Francesco;Pecorella, Irene;Mancino, Pasquale;Piccioni, Maria GraziaPenultimo
;Benedetti Panici, PierluigiUltimo
2017
Abstract
Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.| File | Dimensione | Formato | |
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Carrone_HPV-related vulvar_2017.pdf
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