Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.

HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature / Carrone, Angela; Riganelli, Lucia; Savone, Delia; Casorelli, Assunta; Merlino, Lucia; Pecorini, Francesco; Pecorella, Irene; Mancino, Pasquale; Piccioni, Maria Grazia; Benedetti Panici, Pierluigi. - In: TUMORI. - ISSN 0300-8916. - STAMPA. - 103:6(2017), pp. 511-515. [10.5301/tj.5000642]

HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature

Carrone, Angela
Primo
;
Riganelli, Lucia
Secondo
;
Savone, Delia
;
Casorelli, Assunta;Merlino, Lucia;Pecorini, Francesco;Pecorella, Irene;Mancino, Pasquale;Piccioni, Maria Grazia
Penultimo
;
Benedetti Panici, Pierluigi
Ultimo
2017

Abstract

Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.
File allegati a questo prodotto
File Dimensione Formato  
Carrone_HPV-related vulvar_2017.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 189.63 kB
Formato Adobe PDF
189.63 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1017242
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 2
social impact