By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography / Mazzoccanti, G; Ismail, O; D'Acquarica, I; Villani, C; Manzo, C; Wilcox, M; Cavazzini, A; Gasparrini, F.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - ELETTRONICO. - 53:91(2017), pp. 12262-12265. [10.1039/c7cc06999e]
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography
Mazzoccanti, G;Ismail, O;D'acquarica, I
;Villani, C;Gasparrini, F.
2017
Abstract
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.| File | Dimensione | Formato | |
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