A series of thermally stable atropisomeric phencyclone ligands (ΔG‡ rac > 35 kcal mol−1), bearing two chiral axes, has been successfully synthesized, taking into account the results of DFT calculations on model systems. The absolute configurations of the novel atropisomers have been assigned using TD-DFT simulation of ECD spectra. Atropisomeric phencyclones herein presented pave the way towards new ruthenium- based enantioselective hydrogenation catalysts
Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality / Prati, L.; Mancinelli, M.; Ciogli, Alessia; Mazzanti, A.. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - ELETTRONICO. - 15:41(2017), pp. 8720-8728. [10.1039/c7ob01455d]
Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality.
CIOGLI, Alessia;
2017
Abstract
A series of thermally stable atropisomeric phencyclone ligands (ΔG‡ rac > 35 kcal mol−1), bearing two chiral axes, has been successfully synthesized, taking into account the results of DFT calculations on model systems. The absolute configurations of the novel atropisomers have been assigned using TD-DFT simulation of ECD spectra. Atropisomeric phencyclones herein presented pave the way towards new ruthenium- based enantioselective hydrogenation catalysts| File | Dimensione | Formato | |
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