Two very recent comprehensive reviews on sperm DNA fragmentation tests (1,2) have reopened the debate over their usefulness in improving pregnancy outcome. In this regards, two considerations should be disentangled. First, spermatozoa are not simply carriers of paternal chromosomes, but play a role beyond fertilization. For instance, the spermatozoon transcribes genes critical for early embryonic development, inferring that integrity of sperm genome is essential for a successful gestation. Second, if sperm factors play a role in early embryonic development, are sperm DNA integrity tests useful as diagnostic and prognostic markers, especially in the context of recurrent pregnancy loss (RPL) ?
DNA fragmentation and the ultimate success of a pregnancy / Giuseppe, Benagiano1; Paoli, Donatella; Lombardo, Francesco; Brosens3, Jan J.; Brosens4, Ivo A.. - In: TRANSLATIONAL ANDROLOGY AND UROLOGY. - ISSN 2223-4683. - STAMPA. - 6:S4(2017), pp. S539-S543. [10.21037/tau.2017.03.46]
DNA fragmentation and the ultimate success of a pregnancy
PAOLI, Donatella;LOMBARDO, Francesco;
2017
Abstract
Two very recent comprehensive reviews on sperm DNA fragmentation tests (1,2) have reopened the debate over their usefulness in improving pregnancy outcome. In this regards, two considerations should be disentangled. First, spermatozoa are not simply carriers of paternal chromosomes, but play a role beyond fertilization. For instance, the spermatozoon transcribes genes critical for early embryonic development, inferring that integrity of sperm genome is essential for a successful gestation. Second, if sperm factors play a role in early embryonic development, are sperm DNA integrity tests useful as diagnostic and prognostic markers, especially in the context of recurrent pregnancy loss (RPL) ?| File | Dimensione | Formato | |
|---|---|---|---|
|
Benagiano_DNA-fragmentation_2017.pdf
solo utenti autorizzati
Note: Articolo principale
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
147.09 kB
Formato
Adobe PDF
|
147.09 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
