First, rule out cancer: giant lipoma

Lipomas, benign tumors of the adipose tissue, consist of adipocytes surrounded by a fibrous capsule, and they can arise in any region of the body. Depending on the anatomical site and dimensions, lipomas can alter movement, become inflamed, and induce lymphedema, pain, and compression syndrome Lipomas larger than 10 cm in maximum diameter or heavier than 1000 g are defined as “giant. Fluorescence in situ hybridization (FISH) can be useful in identifying liposarcomas. Amplification of MDM-2 and CDK4 genes strongly indicates this type of neoplasm. Immunostaining has limited value, since vimentin and S100 protein are found in both lipoma and liposarcoma