In multicellular organisms, a stringent control of the transitionbetween cell division and differentiation is crucial for correcttissue and organ development. In theArabidopsisroot, the bound-ary between dividing and differentiating cells is positioned by theantagonistic interaction of the hormones auxin and cytokinin. Cy-tokinin affects polar auxin transport, but how this impacts thepositional information required to establish this tissue boundary,is still unknown. By combining computational modeling with mo-lecular genetics, we show that boundary formation is dependenton cytokinin’s control on auxin polar transport and degradation.The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the bound-ary between dividing and differentiating cells, acting as a triggerfor this developmental transition, thus controlling meristem size.

Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root / DI MAMBRO, Riccardo; DE RUVO, Micol; Pacifici, Elena; Salvi, Elena; Sozzani, Rosangela; Benfey, Philip N.; Busch, Wolfgang; Novak, Ondrej; Ljung, Karin; DI PAOLA, Luisa; Marã©e, Athanasius F. M.; Costantino, Paolo; Grieneisen, Verônica A; Sabatini, Sabrina. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - ELETTRONICO. - 114:36(2017), pp. E7641-E7649. [10.1073/pnas.1705833114]

Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root

DI MAMBRO, RICCARDO;DE RUVO, MICOL;PACIFICI, ELENA;SALVI, ELENA;DI PAOLA, Luisa;COSTANTINO, Paolo;SABATINI, Sabrina
2017

Abstract

In multicellular organisms, a stringent control of the transitionbetween cell division and differentiation is crucial for correcttissue and organ development. In theArabidopsisroot, the bound-ary between dividing and differentiating cells is positioned by theantagonistic interaction of the hormones auxin and cytokinin. Cy-tokinin affects polar auxin transport, but how this impacts thepositional information required to establish this tissue boundary,is still unknown. By combining computational modeling with mo-lecular genetics, we show that boundary formation is dependenton cytokinin’s control on auxin polar transport and degradation.The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the bound-ary between dividing and differentiating cells, acting as a triggerfor this developmental transition, thus controlling meristem size.
2017
cell differentiation; computational modeling; plant hormones; root meristem; multidisciplinary
01 Pubblicazione su rivista::01a Articolo in rivista
Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root / DI MAMBRO, Riccardo; DE RUVO, Micol; Pacifici, Elena; Salvi, Elena; Sozzani, Rosangela; Benfey, Philip N.; Busch, Wolfgang; Novak, Ondrej; Ljung, Karin; DI PAOLA, Luisa; Marã©e, Athanasius F. M.; Costantino, Paolo; Grieneisen, Verônica A; Sabatini, Sabrina. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - ELETTRONICO. - 114:36(2017), pp. E7641-E7649. [10.1073/pnas.1705833114]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1006715
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