Bacterial infections pose a huge concern for human health in terms of increased morbidity, mortality and healthcare costs. Two main issues contribute to render the treatment of some infectious diseases a difficult task: anti-microbial resistance (AMR) and the development of microbial biofilms.The aim of the work described in this thesis is the development of liposomes that, properly functionalized and loaded, could have a potential application in the diagnosis of bacterial infections and in the relative therapy. The chosen strategy to achieve the selective recognition of bacteria by liposomes is based on the decoration of vesicles surface with saccharide moieties that might ascribe to them specificity toward lectins and carbohydrate-receptors located on microbial cells. For what concerns the diagnosis, a further functionalization of the lipid bilayer capable of generating a specific optical response upon the interaction with pathogens is required; to achieve this goal, the chromo-responsive polydiacetylene (PDA) liposomes containing the π-conjugate “ene-yne” backbone were selected as suitable vesicular platform.

Glycosylated liposomes: a potential tool for the detection and treatment of bacterial infections / Mauceri, Alessandro. - (2017 Sep 22).

Glycosylated liposomes: a potential tool for the detection and treatment of bacterial infections

MAUCERI, ALESSANDRO
22/09/2017

Abstract

Bacterial infections pose a huge concern for human health in terms of increased morbidity, mortality and healthcare costs. Two main issues contribute to render the treatment of some infectious diseases a difficult task: anti-microbial resistance (AMR) and the development of microbial biofilms.The aim of the work described in this thesis is the development of liposomes that, properly functionalized and loaded, could have a potential application in the diagnosis of bacterial infections and in the relative therapy. The chosen strategy to achieve the selective recognition of bacteria by liposomes is based on the decoration of vesicles surface with saccharide moieties that might ascribe to them specificity toward lectins and carbohydrate-receptors located on microbial cells. For what concerns the diagnosis, a further functionalization of the lipid bilayer capable of generating a specific optical response upon the interaction with pathogens is required; to achieve this goal, the chromo-responsive polydiacetylene (PDA) liposomes containing the π-conjugate “ene-yne” backbone were selected as suitable vesicular platform.
22-set-2017
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1005640
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact