Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up.
Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel / Ferlito, Claudia; Barnaba, Vincenzo; Abrignani, Sergio; Bombaci, Mauro; Sette, Alessandro; Sidney, John; Biselli, Roberto; Tomao, Enrico; Cattaruzza, Maria Sofia; Germano, Valentina; Biondo, MICHELA ILEEN; Salerno, Gerardo; Lulli, Patrizia; Caporuscio, Sara; PICCHIANTI DIAMANTI, Andrea; Falco, Mirella; Biselli, Valentina; Cardelli, Patrizia; Autore, ALBERTO MARIA; Lucertini, Elena; DE CESARE, DONATO POMPEO; Peragallo, Mario Stefano; Lista, Florigio; Martire, Carmela; Salemi, Simonetta; Nisini, Roberto; D'Amelio, Raffaele. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - STAMPA. - 181:(2017), pp. 60-66. [10.1016/j.clim.2017.06.001]
Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel
FERLITO, CLAUDIA;BARNABA, Vincenzo;ABRIGNANI, SERGIO;SETTE, Alessandro;CATTARUZZA, Maria Sofia;GERMANO, VALENTINA;BIONDO, MICHELA ILEEN;SALERNO, GERARDO;LULLI, Patrizia;CAPORUSCIO, SARA;PICCHIANTI DIAMANTI, Andrea;FALCO, Mirella;CARDELLI, Patrizia;LUCERTINI, ELENA;DE CESARE, DONATO POMPEO;MARTIRE, CARMELA;D'AMELIO, Raffaele
2017
Abstract
Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up.File | Dimensione | Formato | |
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Ferlito_Lack-of-evidence_2017.pdf
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