We applied exact low-resolution brain electromagnetic tomography (eLORETA) method to auditory startle event-related potentials (ERPs) during cold pain (cold-cup-test: CCT). ERPs and startle data were obtained from a published dataset wherein auditory startle stimuli were used as probes of pain processing (De Pascalis & Scacchia, 2016). We wanted to identify (1) sources of cortical current density changes associated with pain/distress reductions to placebo analgesia (PA) treatment, and (2) sources of activity changes that are predictors of the behavioural inhibition system (BIS) and fight/flight/freeze system (FFFS) of the revised Reinforcement Sensitivity Theory (rRST). We administered three treatments: Baseline, CCT-alone (Pain), and CCT plus sham cream (Placebo). PA, as compared to Pain treatment, was effective in pain and distress reduction, and produced a significant current density reduction within right primary somatosensory cortex (S1) and left middle frontal gyrus (MFG). In addition, current density change in the right S1 was a positive predictor of subjective pain and distress reduction, although distress reduction was also associated with decreased activity in the left MFG. We failed to identify regional sources of placebo-related current density changes as predictors of the BIS and FFFS with the exception of current density changes within left MFG that was positively correlated with BIS and a significant predictor of this trait. Findings appear consistent with rRST predictions suggesting BIS and FFFS as separate, but interacting neurobehavioural systems.

Personality and placebo analgesia during cold stimulation in women: A Low-Resolution Brain Electromagnetic Tomography (LORETA) analysis of startle ERPs / DE PASCALIS, Vilfredo; Scacchia, Paolo. - In: PERSONALITY AND INDIVIDUAL DIFFERENCES. - ISSN 0191-8869. - STAMPA. - 118:(2017), pp. 64-70. [10.1016/j.paid.2017.02.046]

Personality and placebo analgesia during cold stimulation in women: A Low-Resolution Brain Electromagnetic Tomography (LORETA) analysis of startle ERPs

DE PASCALIS, Vilfredo;SCACCHIA, PAOLO
2017

Abstract

We applied exact low-resolution brain electromagnetic tomography (eLORETA) method to auditory startle event-related potentials (ERPs) during cold pain (cold-cup-test: CCT). ERPs and startle data were obtained from a published dataset wherein auditory startle stimuli were used as probes of pain processing (De Pascalis & Scacchia, 2016). We wanted to identify (1) sources of cortical current density changes associated with pain/distress reductions to placebo analgesia (PA) treatment, and (2) sources of activity changes that are predictors of the behavioural inhibition system (BIS) and fight/flight/freeze system (FFFS) of the revised Reinforcement Sensitivity Theory (rRST). We administered three treatments: Baseline, CCT-alone (Pain), and CCT plus sham cream (Placebo). PA, as compared to Pain treatment, was effective in pain and distress reduction, and produced a significant current density reduction within right primary somatosensory cortex (S1) and left middle frontal gyrus (MFG). In addition, current density change in the right S1 was a positive predictor of subjective pain and distress reduction, although distress reduction was also associated with decreased activity in the left MFG. We failed to identify regional sources of placebo-related current density changes as predictors of the BIS and FFFS with the exception of current density changes within left MFG that was positively correlated with BIS and a significant predictor of this trait. Findings appear consistent with rRST predictions suggesting BIS and FFFS as separate, but interacting neurobehavioural systems.
2017
auditory startle response; distress reduction; event-related potentials; LORETA; pain reduction; placebo; tonic cold-pain; psychology (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Personality and placebo analgesia during cold stimulation in women: A Low-Resolution Brain Electromagnetic Tomography (LORETA) analysis of startle ERPs / DE PASCALIS, Vilfredo; Scacchia, Paolo. - In: PERSONALITY AND INDIVIDUAL DIFFERENCES. - ISSN 0191-8869. - STAMPA. - 118:(2017), pp. 64-70. [10.1016/j.paid.2017.02.046]
File allegati a questo prodotto
File Dimensione Formato  
de-pascalis_personality_2017.pdf

solo utenti autorizzati

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 384.26 kB
Formato Adobe PDF
384.26 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1000137
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 6
social impact