Peripheral neuropathies are common neurologic disorders, but current treatments are limited. Among the different approaches to treat the acquired neuropathies due to traumatic injuries, the pharmacological interventions directed to Schwann cell may represent a useful and challenging opportunity. Following nerve damage the distal axon and the ensheathing Schwann cells degenerate, ensuing a process known as "Wallerian degeneration". Schwann cells then dedifferentiate and proliferate to support neurite outgrowth. In the recent years, several pharmacological agents that may promote the Schwann cell in its role of supporting nerve regeneration have been proposed. However, in view of increased understanding of the cellular mechanisms controlling neuron-glial interactions, a great attention has focused on neurotransmitters, neuroactive steroids, and neurohormones. In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury.

Chapter 15 Novel Pharmacological Approaches to Schwann Cells as Neuroprotective Agents for Peripheral Nerve Regeneration / Magnaghi, Valerio; Procacci, Patrizia; Tata, Ada Maria. - 87(2009), pp. 295-315. - INTERNATIONAL REVIEW OF NEUROBIOLOGY. [10.1016/S0074-7742(09)87015-3].

Chapter 15 Novel Pharmacological Approaches to Schwann Cells as Neuroprotective Agents for Peripheral Nerve Regeneration

MAGNAGHI, VALERIO;PROCACCI, PATRIZIA;TATA, Ada Maria
2009

Abstract

Peripheral neuropathies are common neurologic disorders, but current treatments are limited. Among the different approaches to treat the acquired neuropathies due to traumatic injuries, the pharmacological interventions directed to Schwann cell may represent a useful and challenging opportunity. Following nerve damage the distal axon and the ensheathing Schwann cells degenerate, ensuing a process known as "Wallerian degeneration". Schwann cells then dedifferentiate and proliferate to support neurite outgrowth. In the recent years, several pharmacological agents that may promote the Schwann cell in its role of supporting nerve regeneration have been proposed. However, in view of increased understanding of the cellular mechanisms controlling neuron-glial interactions, a great attention has focused on neurotransmitters, neuroactive steroids, and neurohormones. In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury.
2009
INTERNATIONAL REVIEW OF NEUROBIOLOGY
9780123750846
Neurology (clinical); Cellular and Molecular Neuroscience
02 Pubblicazione su volume::02a Capitolo o Articolo
Chapter 15 Novel Pharmacological Approaches to Schwann Cells as Neuroprotective Agents for Peripheral Nerve Regeneration / Magnaghi, Valerio; Procacci, Patrizia; Tata, Ada Maria. - 87(2009), pp. 295-315. - INTERNATIONAL REVIEW OF NEUROBIOLOGY. [10.1016/S0074-7742(09)87015-3].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/963147
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