Alcohol and nicotine dependence are the most serious public health problems worldwide in terms of health care costs, social impact, morbidity, and mortality rates. In this chapter, we review the latest theories on the neurobiology of addiction, with an emphasis on alcohol and nicotine co-occurrence, focusing specifically on nicotinic cholinergic mechanisms and their interaction with other critical neurochemical systems. Finally, we discuss the role of the partial nicotinic agonist, varenicline, in the treatment of nicotine dependence and its potential utility in the treatment of alcohol dependence.
New Insight into Alcohol and Nicotine Addiction: Neurobiological Findings and Therapeutical Perspectives / Vitali, Mario; Battagliese, Gemma; Ceccanti, Mauro. - 3(2016), pp. 860-871. [10.1016/B978-0-12-800634-4.00085-8].
New Insight into Alcohol and Nicotine Addiction: Neurobiological Findings and Therapeutical Perspectives
VITALI, MARIO;BATTAGLIESE, GEMMA;CECCANTI, Mauro
2016
Abstract
Alcohol and nicotine dependence are the most serious public health problems worldwide in terms of health care costs, social impact, morbidity, and mortality rates. In this chapter, we review the latest theories on the neurobiology of addiction, with an emphasis on alcohol and nicotine co-occurrence, focusing specifically on nicotinic cholinergic mechanisms and their interaction with other critical neurochemical systems. Finally, we discuss the role of the partial nicotinic agonist, varenicline, in the treatment of nicotine dependence and its potential utility in the treatment of alcohol dependence.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
