The Western explanation for acupuncture effectiveness is based upon more than half a century of basic and clinical research, which identified the activation of sensory system and the subsequent activity-dependent regulation of neurotransmitters, neurohormones, and several classes of neuromodulators as plausible mechanism for the acupuncture's therapeutic properties. The regulation of neurotrophins' expression and activity is one of the possible neurophysiological mechanisms underlying acupuncture's effects on neuropathic pain, nerve injury, neurodegeneration, and even in the regulation of gonadal functions. The present work will review the scientific literature produced by a decade of investigations on the relationship between acupuncture and neurotrophins. This scientific production and the current knowledge about the neural and neurohormonal activity-dependent regulation of neurotrophin expression/action suggest the existence of a link between the ability of acupuncture in regulating neural physiology and its effects on the neurotrophic milieu in different disease states.

Acupuncture and neurotrophin modulation / Soligo, Marzia; Nori, Sl; Protto, V; Florenzano, F; Manni, L.. - ELETTRONICO. - (2013), pp. 91-124. - INTERNATIONAL REVIEW OF NEUROBIOLOGY.

Acupuncture and neurotrophin modulation

SOLIGO, Marzia;Protto V;
2013

Abstract

The Western explanation for acupuncture effectiveness is based upon more than half a century of basic and clinical research, which identified the activation of sensory system and the subsequent activity-dependent regulation of neurotransmitters, neurohormones, and several classes of neuromodulators as plausible mechanism for the acupuncture's therapeutic properties. The regulation of neurotrophins' expression and activity is one of the possible neurophysiological mechanisms underlying acupuncture's effects on neuropathic pain, nerve injury, neurodegeneration, and even in the regulation of gonadal functions. The present work will review the scientific literature produced by a decade of investigations on the relationship between acupuncture and neurotrophins. This scientific production and the current knowledge about the neural and neurohormonal activity-dependent regulation of neurotrophin expression/action suggest the existence of a link between the ability of acupuncture in regulating neural physiology and its effects on the neurotrophic milieu in different disease states.
2013
International Review of Neurobiology
Acupuncture; BDNF; NGF; NT-3; NT-4; Neurotrophins; Physical therapy; Sortilin; Trk; p75(NTR)
02 Pubblicazione su volume::02a Capitolo o Articolo
Acupuncture and neurotrophin modulation / Soligo, Marzia; Nori, Sl; Protto, V; Florenzano, F; Manni, L.. - ELETTRONICO. - (2013), pp. 91-124. - INTERNATIONAL REVIEW OF NEUROBIOLOGY.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/850056
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