Stress-related events that occur in the perinatal period can permanently change brain and behavior of the developing individual and there is increasing evidence that early-life adversity is a contributing factor in the etiology of drug abuse and mood disorders. Neural adaptations resulting from early-life stress may mediate individual differences in novelty responsiveness and in turn contribute to drug abuse vulnerability. Prenatal restraint stress (PRS) in rats is a well-documented model of early stress known to induce long-lasting neurobiological and behavioral alterations including impaired feedback mechanisms of the HPA axis, enhanced novelty seeking, and increased sensitiveness to psychostimulants as well as anxiety/depression-like behavior. Together with the HPA axis, functional alterations of the mesolimbic dopamine system and of the metabotropic glutamate receptors system appear to be involved in the addiction-like profile of PRS rats.

A self-medication hypothesis for increased vulnerability to drug abuse in prenatally restraint stressed rats / Reynaert, Marie Line; Marrocco, Jordan; Gatta, Eleonora; Mairesse, Jérôme; Van Camp, Gilles; Fagioli, Francesca; Maccari, Stefania; Nicoletti, Ferdinando; Morley Fletcher, Sara. - 10(2015), pp. 101-120. - ADVANCES IN NEUROBIOLOGY. [10.1007/978-1-4939-1372-5_6].

A self-medication hypothesis for increased vulnerability to drug abuse in prenatally restraint stressed rats

MACCARI, STEFANIA;NICOLETTI, Ferdinando;
2015

Abstract

Stress-related events that occur in the perinatal period can permanently change brain and behavior of the developing individual and there is increasing evidence that early-life adversity is a contributing factor in the etiology of drug abuse and mood disorders. Neural adaptations resulting from early-life stress may mediate individual differences in novelty responsiveness and in turn contribute to drug abuse vulnerability. Prenatal restraint stress (PRS) in rats is a well-documented model of early stress known to induce long-lasting neurobiological and behavioral alterations including impaired feedback mechanisms of the HPA axis, enhanced novelty seeking, and increased sensitiveness to psychostimulants as well as anxiety/depression-like behavior. Together with the HPA axis, functional alterations of the mesolimbic dopamine system and of the metabotropic glutamate receptors system appear to be involved in the addiction-like profile of PRS rats.
2015
Perinatal Programming of Neurodevelopment
978-1-4939-1371-8
978-1-4939-1372-5
978-1-4939-1371-8
978-1-4939-1372-5
02 Pubblicazione su volume::02a Capitolo o Articolo
A self-medication hypothesis for increased vulnerability to drug abuse in prenatally restraint stressed rats / Reynaert, Marie Line; Marrocco, Jordan; Gatta, Eleonora; Mairesse, Jérôme; Van Camp, Gilles; Fagioli, Francesca; Maccari, Stefania; Nicoletti, Ferdinando; Morley Fletcher, Sara. - 10(2015), pp. 101-120. - ADVANCES IN NEUROBIOLOGY. [10.1007/978-1-4939-1372-5_6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/845230
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