Infection with human immunodeficiency virus (HIV) is characterised by a progressive decrease in CD4+ T cell number with a consequent impairment of the immune response and the onset of opportunistic infections and neoplasms. The mechanism responsible of CD4 T cell depletion is mainly the induction of apoptosis, which can be activated by HIV through various pathways. In this chapter direct and indirect mechanisms of HIV-induced apoptosis in infected and uninfected bystander cells are described.
Apoptosis induction in T lymphocytes by HIV / GILARDINI MONTANI, MARIA SAVERIA. - STAMPA. - 2(2007), pp. 295-311. [10.1007/978-1-59745-199-4_14].