Purpose: The aim of the present work was to show the potential neuroprotective activity of forskolin, a receptor-independent activator of adenylate-cyclase, in an experimental model of ocular hypertension in the rat. Methods: Methylcellulose at 2% was injected into the anterior chamber of rat eyes to induce IOP elevation. Animals were either treated or not with forskolin (1 mg/Kg) in their diet. Results: Seven days after IOP elevation, rat retinas were evaluated for apoptosis (TUNEL and caspase 3) and iNOS. Forskolin treatment resulted in a reduced increase of IOP after methylcellulose injection, and a decreased production of iNOS, that resulted in a reduced expression of caspase 3 and TUNEL positive cells. Conclusion: The combined action on IOP and neuron survival suggests a neuroprotective activity of forskolin in glaucomatous neurodegenerative disease, in which elevated IOP is the main risk factor, but not the only determinant of the progressive death of retinal ganglion cells

ORAL ADMINISTRATION OF FORSKOLIN DECREASES RETINAL DAMAGE AFTER EXPERIMENTAL INDUCTION OF OCULAR HYPERTENSION IN THE RAT / Pescosolido, Nicola; Scarsella, Gianfranco; Dario, Rusciano. - STAMPA. - (2015), pp. 31-50.

ORAL ADMINISTRATION OF FORSKOLIN DECREASES RETINAL DAMAGE AFTER EXPERIMENTAL INDUCTION OF OCULAR HYPERTENSION IN THE RAT

PESCOSOLIDO, Nicola;SCARSELLA, Gianfranco;
2015

Abstract

Purpose: The aim of the present work was to show the potential neuroprotective activity of forskolin, a receptor-independent activator of adenylate-cyclase, in an experimental model of ocular hypertension in the rat. Methods: Methylcellulose at 2% was injected into the anterior chamber of rat eyes to induce IOP elevation. Animals were either treated or not with forskolin (1 mg/Kg) in their diet. Results: Seven days after IOP elevation, rat retinas were evaluated for apoptosis (TUNEL and caspase 3) and iNOS. Forskolin treatment resulted in a reduced increase of IOP after methylcellulose injection, and a decreased production of iNOS, that resulted in a reduced expression of caspase 3 and TUNEL positive cells. Conclusion: The combined action on IOP and neuron survival suggests a neuroprotective activity of forskolin in glaucomatous neurodegenerative disease, in which elevated IOP is the main risk factor, but not the only determinant of the progressive death of retinal ganglion cells
2015
Forskolin: Sources, Mechanisms of Action and Health Effects
9781634639446
glaucoma; IOP; forskolin; neuroprotection; neurotrophins
02 Pubblicazione su volume::02a Capitolo o Articolo
ORAL ADMINISTRATION OF FORSKOLIN DECREASES RETINAL DAMAGE AFTER EXPERIMENTAL INDUCTION OF OCULAR HYPERTENSION IN THE RAT / Pescosolido, Nicola; Scarsella, Gianfranco; Dario, Rusciano. - STAMPA. - (2015), pp. 31-50.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/776576
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