The COP9 signalosome (CSN) is an evolutionary conserved multiprotein complex that functions in the ubiquitin-proteasome pathway. The CSN has an isopeptidase activity which removes the NEDD8 peptide from the cullin-RING ubiquitin ligases (CRLs). This reaction ensures the proper function of the CRLs. The CSN is involved in the control of multiple signaling processes in virtually all eukaryotes. In plants, the CSN takes part in a plethora of developmental processes and environmental responses, including photomorphogenesis, flower development, hormone signaling and plant pathogen response. The CSN is also required for the regulation of cellular pathways, such as cell cycle, DNA repair and regulation of gene expression.
Signaling: The COP9 signalosome / Franciosini, Anna; Serino, Giovanna; Deng, X. W.. - STAMPA. - II(2014), pp. 313-332. [10.1007/SpringerReference_349844 2013-08-05 04:28:44 UTC].
Signaling: The COP9 signalosome
FRANCIOSINI, ANNA;SERINO, Giovanna;
2014
Abstract
The COP9 signalosome (CSN) is an evolutionary conserved multiprotein complex that functions in the ubiquitin-proteasome pathway. The CSN has an isopeptidase activity which removes the NEDD8 peptide from the cullin-RING ubiquitin ligases (CRLs). This reaction ensures the proper function of the CRLs. The CSN is involved in the control of multiple signaling processes in virtually all eukaryotes. In plants, the CSN takes part in a plethora of developmental processes and environmental responses, including photomorphogenesis, flower development, hormone signaling and plant pathogen response. The CSN is also required for the regulation of cellular pathways, such as cell cycle, DNA repair and regulation of gene expression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
