Hemicerebellectomy (HCB) is characterized by ablation of half of the vermis with one cerebellar hemisphere, including the deep cerebellar nuclei, while sparing the vestibular nuclei and all surrounding structures. This approach has been adopted widely by many groups mainly in rats in various contexts of research. The purpose of this chapter is to review old and recent data focusing on morphological as well as functional data obtained in this model in addressing cerebellar function and brain plasticity mechanisms.
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