Theoretical prediction of sequence dependent DNAs superstructures and their implications in recognition mechanisms with proteins.

DNA has an intrinsic ability to translate the deterministic fluctuations of the base sequence in superstructural elements. Many biosynthetic and biologically relevant DNAs were found intrinsically bent as monitored by their elecrophoretic retardation. Moreover, binding proteins to specific DNA regions often produce an induced curvature or amplify the intrinsic curvature. In this paper we report a theoretical model for the predictions of intrinsic and induced superstructures of DNA tracts and their electrophoretic manifestations.