Heterologous products from the yeast Kluyveromyces lactis: exploitation of KlPDC1, a single-gene based system

Heterologous products are frequent applications of microbial technology. Depending on the product, the host-vector system has to be chosen in order to fulfill process requirements. This short review summarizes published and unpublished results obtained for the production of heterologous metabolites and proteins from a single host, the yeast Kluyveromyces lactis, and by means of tools – promoter, mutant strains, regulators – uniquely from the single gene KlPDC1. We will describe the production of lactic acid and various bacterial, viral, fungal and mammal proteins or enzymes: b-galactosidase, Hepatitis C viral protein c-33, laccase, glucoamylase and interleukine-1b.