In the last decade, dramatic progress has been made in elucidating the molecular defects underlying a number of muscle diseases. With the characterization of mutations responsible for muscle dysfunction in several inherited pathologies, and the identification of novel signaling pathways, subtle alterations in which can lead to significant defects in muscle metabolism, the field is poised to devise successful strategies for treatment of this debilitating and often fatal group of human ailments. Yet progress has been slow in therapeutic applications of our newly gained knowledge. The complexity of muscle types, the intimate relationship between structural integrity and mechanical function, and the sensitivity of skeletal muscle to metabolic perturbations have impeded rapid progress in successful clinical intervention. The relatively poor regenerative properties of striated muscle compound the devastating effects of muscle degeneration. Perhaps the most difficult hurdle is the sheer volume of tissue that must be treated to effect a significant improvement in quality of life. Recent studies on the role of insulin-like growth factor-1 in skeletal muscle growth and homeostasis have excited new interest in this important mediator of anabolic pathways and suggest promising new avenues for intervention in catabolic disease. In this review, we will discuss the potential therapeutic role of local insulin-like growth factor 1 in the treatment of muscle wasting associated with muscle diseases. Copyright (C) 2009 S. Karger AG, Basel

Muscle Involvement and IGF-1 Signaling in Genetic Disorders: New Therapeutic Approaches / Barberi, Laura; Dobrowolny, Gabriella; Pelosi, Laura; Giacinti, Cristina; Musaro', Antonio. - 14(2009), pp. 29-37. ((Intervento presentato al convegno Workshop on Endocrine Involvement in Development Syndromes tenutosi a Rome, ITALY nel APR 21-22, 2008. - ENDOCRINE DEVELOPMENT. [10.1159/000207474].

Muscle Involvement and IGF-1 Signaling in Genetic Disorders: New Therapeutic Approaches

BARBERI, laura;DOBROWOLNY, Gabriella;PELOSI, LAURA;GIACINTI, Cristina;MUSARO', Antonio
2009

Abstract

In the last decade, dramatic progress has been made in elucidating the molecular defects underlying a number of muscle diseases. With the characterization of mutations responsible for muscle dysfunction in several inherited pathologies, and the identification of novel signaling pathways, subtle alterations in which can lead to significant defects in muscle metabolism, the field is poised to devise successful strategies for treatment of this debilitating and often fatal group of human ailments. Yet progress has been slow in therapeutic applications of our newly gained knowledge. The complexity of muscle types, the intimate relationship between structural integrity and mechanical function, and the sensitivity of skeletal muscle to metabolic perturbations have impeded rapid progress in successful clinical intervention. The relatively poor regenerative properties of striated muscle compound the devastating effects of muscle degeneration. Perhaps the most difficult hurdle is the sheer volume of tissue that must be treated to effect a significant improvement in quality of life. Recent studies on the role of insulin-like growth factor-1 in skeletal muscle growth and homeostasis have excited new interest in this important mediator of anabolic pathways and suggest promising new avenues for intervention in catabolic disease. In this review, we will discuss the potential therapeutic role of local insulin-like growth factor 1 in the treatment of muscle wasting associated with muscle diseases. Copyright (C) 2009 S. Karger AG, Basel
2009
Endocrine Involvement in Developmental Syndromes
9783805590419
02 Pubblicazione su volume::02a Capitolo o Articolo
Muscle Involvement and IGF-1 Signaling in Genetic Disorders: New Therapeutic Approaches / Barberi, Laura; Dobrowolny, Gabriella; Pelosi, Laura; Giacinti, Cristina; Musaro', Antonio. - 14(2009), pp. 29-37. ((Intervento presentato al convegno Workshop on Endocrine Involvement in Development Syndromes tenutosi a Rome, ITALY nel APR 21-22, 2008. - ENDOCRINE DEVELOPMENT. [10.1159/000207474].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/358244
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