Amphibian skin is a rich source of biologically active compounds, such as amines, complex alkaloids or peptides and proteins which are produced by holocrine-type serous glands, where they are stored and released upon stimulation. In particular, a high number of gene-encoded antimicrobial peptides have been isolated and characterised from amphibian skin secretions, containing 10-50 amino acid residues. Several of these peptides are characterised by posttranslational modifications, such as amidation at the C-terminal end or isomerization of an L-amino acid to the corresponding D-isomer. Here, the structural and functional properties of amphibian antimicrobial peptides, as well as the mechanisms regulating their synthesis are reviewed.

Defence peptides in the amphibian immune system

SIMMACO, Maurizio;MANGONI, Maria Luisa;MIELE, Rossella;BARRA, Donatella
2003

Abstract

Amphibian skin is a rich source of biologically active compounds, such as amines, complex alkaloids or peptides and proteins which are produced by holocrine-type serous glands, where they are stored and released upon stimulation. In particular, a high number of gene-encoded antimicrobial peptides have been isolated and characterised from amphibian skin secretions, containing 10-50 amino acid residues. Several of these peptides are characterised by posttranslational modifications, such as amidation at the C-terminal end or isomerization of an L-amino acid to the corresponding D-isomer. Here, the structural and functional properties of amphibian antimicrobial peptides, as well as the mechanisms regulating their synthesis are reviewed.
8127100374
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/247962
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