Hierarchical self-assembly is nature’s solution to the build up of complex structures starting from components that are orders of magnitude smaller. The components are brought together in a precisely defined way by recognition processes based on non-covalent interactions. This offers the possibility for error correction through a continuous sequence of trial and error steps to optimize functionality. Under a set of hierarchical assembly instructions, the functional aggregates produced at each level are the building blocks for the self-assembly at the next higher level of complexity. The information needed for the formation of the resulting structures is encoded within the covalent structure of the subunits. This integration of components over disparate length scales might include inorganic matter. The inorganic matter can be a surface upon which the assembled organic structure is transferred from a 3D to a quasi-2D space. This could lead to functional nanodevices with properties that do not exist, not only in the individual components but also in the organic assembled structure alone. Thiol and silane covalent linkages have so far dominated the field of selfassembled molecules on solid substrates. On the other hand, if we want to build up complex molecular constructions under the full control of a sequence of hierarchical self-assembling steps, also the interface with the solid surface must rely on a recognition process based on non-covalent interactions. Much effort is now paid to understanding how the organizational capabilities of biological molecules can be combined with inorganic systems in self-assembly processes, and to identify the appropriate compatibilities and combinations of biological macromolecules with inorganic materials.
Towards an increase of the hierarchy in the construction of DNA-based nanostructures through the integration of inorganic materials / B., Samorì; G., Zuccheri; Scipioni, Anita; P., De Santis. - STAMPA. - unico(2006), pp. 215-249.
Towards an increase of the hierarchy in the construction of DNA-based nanostructures through the integration of inorganic materials.
SCIPIONI, Anita;
2006
Abstract
Hierarchical self-assembly is nature’s solution to the build up of complex structures starting from components that are orders of magnitude smaller. The components are brought together in a precisely defined way by recognition processes based on non-covalent interactions. This offers the possibility for error correction through a continuous sequence of trial and error steps to optimize functionality. Under a set of hierarchical assembly instructions, the functional aggregates produced at each level are the building blocks for the self-assembly at the next higher level of complexity. The information needed for the formation of the resulting structures is encoded within the covalent structure of the subunits. This integration of components over disparate length scales might include inorganic matter. The inorganic matter can be a surface upon which the assembled organic structure is transferred from a 3D to a quasi-2D space. This could lead to functional nanodevices with properties that do not exist, not only in the individual components but also in the organic assembled structure alone. Thiol and silane covalent linkages have so far dominated the field of selfassembled molecules on solid substrates. On the other hand, if we want to build up complex molecular constructions under the full control of a sequence of hierarchical self-assembling steps, also the interface with the solid surface must rely on a recognition process based on non-covalent interactions. Much effort is now paid to understanding how the organizational capabilities of biological molecules can be combined with inorganic systems in self-assembly processes, and to identify the appropriate compatibilities and combinations of biological macromolecules with inorganic materials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.