Systemic lupus erythematosus (SLE) represents the paradigm of systemic autoimmune disease, characterized by a wide range of clinical manifestations and the production of multiple autoantibodies. The diagnosis is based on the clinical features along with the presence of a wide variety of autoantibodies, most of which are directed against double-stranded DNA (ds-DNA), nuclear antigens, ribonucleoproteins, and cell surface antigens. The treatment relies on antimalarials, corticosteroids, conventional immunosuppressors, and new biological agents.
Systemic Lupus Erythematosus / Barilaro, Giuseppe; Espinosa, Gerard; Cervera, Ricard. - (2025), pp. 3-9. [10.1007/978-3-031-69895-8_1].
Systemic Lupus Erythematosus
Barilaro, GiuseppePrimo
Conceptualization
;Cervera, Ricard
2025
Abstract
Systemic lupus erythematosus (SLE) represents the paradigm of systemic autoimmune disease, characterized by a wide range of clinical manifestations and the production of multiple autoantibodies. The diagnosis is based on the clinical features along with the presence of a wide variety of autoantibodies, most of which are directed against double-stranded DNA (ds-DNA), nuclear antigens, ribonucleoproteins, and cell surface antigens. The treatment relies on antimalarials, corticosteroids, conventional immunosuppressors, and new biological agents.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
