Microglia, which are the resident immune cells of the CNS, also have important functions in physiological conditions. In this chapter, we review the experimental evidence that microglia modulate neuronal and synaptic activity during normal development and in adults. We show that microglia can regulate the maturation and function of both inhibitory and excitatory synapses that can be stimulated or repressed. We further review the fact that these regulations occur in various brain regions, through soluble and membrane molecules, directly or through other cell partners. This review emphasizes the fact that microglia are genuine and highly context-dependent and thus adaptable regulators of neuronal activity.

Microglial Modulation of Synaptic Maturation, Activity, and Plasticity / Pinto, Maria Joana; Ragozzino, Davide; Bessis, Alain; Audinat, Etienne. - (2024), pp. 209-219. - ADVANCES IN NEUROBIOLOGY. [10.1007/978-3-031-55529-9_12].

Microglial Modulation of Synaptic Maturation, Activity, and Plasticity

Ragozzino, Davide
Secondo
Writing – Review & Editing
;
2024

Abstract

Microglia, which are the resident immune cells of the CNS, also have important functions in physiological conditions. In this chapter, we review the experimental evidence that microglia modulate neuronal and synaptic activity during normal development and in adults. We show that microglia can regulate the maturation and function of both inhibitory and excitatory synapses that can be stimulated or repressed. We further review the fact that these regulations occur in various brain regions, through soluble and membrane molecules, directly or through other cell partners. This review emphasizes the fact that microglia are genuine and highly context-dependent and thus adaptable regulators of neuronal activity.
2024
Microglia Physiology, Pathophysiology and Therapeutic Potential
9783031555282
9783031555299
ATP; Inflammation; Neuronal development; Neuronal network; Synapse; Synapse maturation
02 Pubblicazione su volume::02a Capitolo o Articolo
Microglial Modulation of Synaptic Maturation, Activity, and Plasticity / Pinto, Maria Joana; Ragozzino, Davide; Bessis, Alain; Audinat, Etienne. - (2024), pp. 209-219. - ADVANCES IN NEUROBIOLOGY. [10.1007/978-3-031-55529-9_12].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1721414
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