Age and Gender Related Paraoxonase I Gene Polymorphisms rs662 and rs854560 in Subjects with Metabolic Syndrome in Fars ethnic group

Background: The aim of the study was to determine the Paraoxonase I Gene Polymorphisms in subjects with and without metabolic syndrome (MetS) in the Fars ethnic group. Methods: Polymorphisms determinationof the paraoxonase1 gene was done by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism analysis in subjects with and without MetS. Results: The MM, LM, and LL genotypes frequencies of the PON1- L55M polymorphism were 2.5, 37.5 and 60%; and 27.5, 34.5 and 38% and; 19.4, 50 and 30.6% and 17.2, 58.6 and 34.2% in females and males with and without MetS, respectively. The QQ, QR, and RR genotypes frequencies of the PON1 - Q192R polymorphism were 50, 47.6 and 2.4%; and 56.8, 34.1 and 9.1% and; 61, 29.2 and 9.8% and 56.3, 35.4 and 8.3% in females and males with and without MetS, respectively. Conclusions: Our study suggested that the decrease of PON1 enzymatic activity in both genders is an important finding, but the L55M genotype in females with MetS is more important than PON1 Q192R polymorphism. This genotyping difference for L55M in females may be important to make the females more vulnerable than males to MetS.