Indoleamine 2,3-dioxygenases, or IDOs, are the main enzymes responsible for the metabolism of l-Tryptophan (Trp), and the open gate of the kynurenine pathway, where the majority of the intake of the essential amino acid is conveyed. The kynurenine pathway produces a great variety of molecules, involved in a great spectrum of physio-pathological mechanisms, spanning from the regulation of the immune response to neurodegenerative diseases, and from maternal-fetal tolerance to cancer. Hence, the understanding of IDOs’ biochemistry, with their fine regulation, represents a fundamental challenge to researchers. In this chapter, we reported the latest discoveries about IDOs also focusing on the development of drugs currently involved in clinical trials.
Indoleamine 2,3-dioxygenase / Coluccia, Michele; Secci, Daniela; Guglielmi, Paolo. - (2023), pp. 485-519. [10.1016/B978-0-12-823974-2.00024-3].
Indoleamine 2,3-dioxygenase
Coluccia, MichelePrimo
Writing – Original Draft Preparation
;Secci, DanielaSecondo
Supervision
;Guglielmi, Paolo
Ultimo
Writing – Original Draft Preparation
2023
Abstract
Indoleamine 2,3-dioxygenases, or IDOs, are the main enzymes responsible for the metabolism of l-Tryptophan (Trp), and the open gate of the kynurenine pathway, where the majority of the intake of the essential amino acid is conveyed. The kynurenine pathway produces a great variety of molecules, involved in a great spectrum of physio-pathological mechanisms, spanning from the regulation of the immune response to neurodegenerative diseases, and from maternal-fetal tolerance to cancer. Hence, the understanding of IDOs’ biochemistry, with their fine regulation, represents a fundamental challenge to researchers. In this chapter, we reported the latest discoveries about IDOs also focusing on the development of drugs currently involved in clinical trials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
