Continuous efforts in the development of monoamine oxidase inhibitors prompted the search for effective strategies for the design of novel drugs candidate. Thankfully, nature often provides scaffolds useful for the promotion of novel exploitable chemical entities. In this regard, aurones (a class of uncommon flavonoids) and their structural related analogues may play an important role in the development of monoamine oxidase inhibitors. The target prediction of the simplest aurone (2- benzylidenebenzofuran-3(2H)-one) clearly suggests that this compound probably affects MAO (monoamine oxidase) enzymes, which is in accordance with the recently reported literature. The current chapter reports the recent discoveries involving aurones and their structurally related analogues as MAO inhibitors, describing detailed structure-activity relationships (SARs) for each subgroup of compounds.
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors / Guglielmi, Paolo; Pontecorvi, Virginia; Akdemir, Atilla. - (2022), pp. 272-297. [10.2174/9789815079098122010012].
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
Guglielmi, Paolo;Pontecorvi, Virginia;
2022
Abstract
Continuous efforts in the development of monoamine oxidase inhibitors prompted the search for effective strategies for the design of novel drugs candidate. Thankfully, nature often provides scaffolds useful for the promotion of novel exploitable chemical entities. In this regard, aurones (a class of uncommon flavonoids) and their structural related analogues may play an important role in the development of monoamine oxidase inhibitors. The target prediction of the simplest aurone (2- benzylidenebenzofuran-3(2H)-one) clearly suggests that this compound probably affects MAO (monoamine oxidase) enzymes, which is in accordance with the recently reported literature. The current chapter reports the recent discoveries involving aurones and their structurally related analogues as MAO inhibitors, describing detailed structure-activity relationships (SARs) for each subgroup of compounds.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.