Although the common strategies to efficiently interfere with cellular pH lie in the direct inhibition of the enzymes/transporters/pumps constituting the cooperative system that controls proton concentration, other approaches can be exploited to obtain similar results. In this respect, it is worthwhile to take into account the effects exhibited by drugs that are not usually considered as pH-interfering agents like HDAC inhibitors and H2S releasing compounds.
Innovative pH-interfering agents in association with anticancer agents / Secci, D.; Guglielmi, P.. - (2020), pp. 121-128. [10.1016/B978-0-12-820701-7.00019-1].
Innovative pH-interfering agents in association with anticancer agents
Secci D.
;Guglielmi P.
2020
Abstract
Although the common strategies to efficiently interfere with cellular pH lie in the direct inhibition of the enzymes/transporters/pumps constituting the cooperative system that controls proton concentration, other approaches can be exploited to obtain similar results. In this respect, it is worthwhile to take into account the effects exhibited by drugs that are not usually considered as pH-interfering agents like HDAC inhibitors and H2S releasing compounds.File allegati a questo prodotto
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