A new electrochemical synthesis of b-lactams has been obtained by electrolysis of CH3CN-TEAP solutions with subsequent addition of bromoamides. The cyclization of these substrates to b-lactams, via N-C4 bond formation, has been induced by electrochemically generated cyanomethyl and aminocrotonitrile anions. This synthesis avoids any peculiar addition of bases and probases and yields b-lactams in high yields.
Electrolyzed CH3CN-Et4NCl4 solutions: an alternative strategy to the synthesis of beta-lactams via C-N bond formation / Rossi, L; Feroci, Marta; Orsini, M; Palombi, L; Inesi, Achille. - STAMPA. - 2004-10(2004), pp. 109-112.
Electrolyzed CH3CN-Et4NCl4 solutions: an alternative strategy to the synthesis of beta-lactams via C-N bond formation
FEROCI, Marta;INESI, ACHILLE
2004
Abstract
A new electrochemical synthesis of b-lactams has been obtained by electrolysis of CH3CN-TEAP solutions with subsequent addition of bromoamides. The cyclization of these substrates to b-lactams, via N-C4 bond formation, has been induced by electrochemically generated cyanomethyl and aminocrotonitrile anions. This synthesis avoids any peculiar addition of bases and probases and yields b-lactams in high yields.File allegati a questo prodotto
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