A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis

Summary points - Congenital insensitivity to pain is a rare autosomal recessive disease characterized by varying degrees of autonomic dysfunction and sensory loss, including nociceptive hyposensitivity. - The molecular genetic defect involves loss of function mutations in the NTRK1 gene, which encodes the tyrosine kinase receptor A gene. This autonomic dysfunction makes both general and neuraxial anesthesia challenging. - Testing the block during neuraxial anesthesia may be difficult, and the patient may be prone to hypotension and bradycardia.