Wound healing is a physiological process that involves several successive and often overlapping phases that lead to the restoration of the integrity of the skin after an injury, accident or surgery: haemostasis and inflammation, proliferation and remodeling. The interruption or slowing down of these processes can cause abnormal or impaired wound healing. There are now numerous data and clinical studies that highlight the roles of estrogens on normal cutaneous homeostasis and wound healing. In postmenopausal women, for example, the reduced speed of wound healing processes has been clearly related to estrogen deficiency, especially in relation to inflammation and re-granulation, while treatment with exogenous estrogens can reverse these effects. We report here on the complex role of estrogens and estrogenic derivatives in wound healing process, with a focus on their therapeutic use, and on which strategies have been explored to find substances with poor systemic effects.

A closer look at wound infections and healing / Filocamo, Luigi; Migneco, Luisa Maria; Ceccacci, Francesca; Leonelli, Francesca. - (2020), pp. 103-128. - NEW DEVELOPMENTS IN MEDICAL RESEARCH.

A closer look at wound infections and healing

Migneco Maria Luisa;Ceccacci Francesca;Leonelli Francesca
2020

Abstract

Wound healing is a physiological process that involves several successive and often overlapping phases that lead to the restoration of the integrity of the skin after an injury, accident or surgery: haemostasis and inflammation, proliferation and remodeling. The interruption or slowing down of these processes can cause abnormal or impaired wound healing. There are now numerous data and clinical studies that highlight the roles of estrogens on normal cutaneous homeostasis and wound healing. In postmenopausal women, for example, the reduced speed of wound healing processes has been clearly related to estrogen deficiency, especially in relation to inflammation and re-granulation, while treatment with exogenous estrogens can reverse these effects. We report here on the complex role of estrogens and estrogenic derivatives in wound healing process, with a focus on their therapeutic use, and on which strategies have been explored to find substances with poor systemic effects.
2020
A closer look at wound infections and healing
9781536168167
wound healing; estrogen; estrogen receptor
02 Pubblicazione su volume::02a Capitolo o Articolo
A closer look at wound infections and healing / Filocamo, Luigi; Migneco, Luisa Maria; Ceccacci, Francesca; Leonelli, Francesca. - (2020), pp. 103-128. - NEW DEVELOPMENTS IN MEDICAL RESEARCH.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1465488
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