Notch is a ligand-receptor interaction-triggered signaling cascade highly conserved, that influences multiple lineage decisions within the hematopoietic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1-4), and each of them plays nonredundant functions at several developmental stages. Canonical and noncanonical pathways of Notch signaling are multifaceted drivers of immune cells biology. In fact, increasing evidence highlighted Notch as an important modulator of immune responses, also in cancer microenvironment. In these contexts, multiple transduction signals, including canonical and alternative NF-κB pathways, play a relevant role. In this chapter, we will first describe the critical role of Notch and NF-κB signals in lymphoid lineages developing in thymus: natural killer T cells, thymocytes, and thymic T regulatory cells. We will address also the role played by ligand expressing cells. Given the importance of Notch/NF-κB cross talk, its role in T-cell leukemia development and progression will be discussed.

Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond / Tsaouli, G.; Barbarulo, A.; Vacca, A.; Screpanti, I.; Felli, M. P.. - (2020), pp. 145-164. - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. [10.1007/978-3-030-36422-9_10].

Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond

Tsaouli G.
Writing – Original Draft Preparation
;
Barbarulo A.
Writing – Original Draft Preparation
;
Vacca A.
Conceptualization
;
Screpanti I.
Supervision
;
Felli M. P.
Ultimo
Writing – Review & Editing
2020

Abstract

Notch is a ligand-receptor interaction-triggered signaling cascade highly conserved, that influences multiple lineage decisions within the hematopoietic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1-4), and each of them plays nonredundant functions at several developmental stages. Canonical and noncanonical pathways of Notch signaling are multifaceted drivers of immune cells biology. In fact, increasing evidence highlighted Notch as an important modulator of immune responses, also in cancer microenvironment. In these contexts, multiple transduction signals, including canonical and alternative NF-κB pathways, play a relevant role. In this chapter, we will first describe the critical role of Notch and NF-κB signals in lymphoid lineages developing in thymus: natural killer T cells, thymocytes, and thymic T regulatory cells. We will address also the role played by ligand expressing cells. Given the importance of Notch/NF-κB cross talk, its role in T-cell leukemia development and progression will be discussed.
2020
Notch signaling in Embriology and Cancer
978-3-030-36421-2
978-3-030-36422-9
innate immune cells; nf-κb; notch; t-cell leukemogenesis; t-cells; animals; humans; lymphocytes; nf-kappa b; receptors, notch; cell lineage; signal transduction
02 Pubblicazione su volume::02a Capitolo o Articolo
Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond / Tsaouli, G.; Barbarulo, A.; Vacca, A.; Screpanti, I.; Felli, M. P.. - (2020), pp. 145-164. - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. [10.1007/978-3-030-36422-9_10].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1368078
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