Intramolecular Oxypalladation and Related Reactions Involving Other Group 16 Atom Nucleophiles: Oxypalladation–Reductive Elimination Domino Reactions with Organopalladium and Hydridopalladium Derivatives

This chapter presents two major topics that pertain to nucleophilic attack on ligands of organopalladium complexes: the Tsuji–Trost reaction and the Wacker oxidation reaction. Related reactions of allylpalladium derivatives and reactions involving Pd π-complexes are also discussed. A brief overview of the well-established chemistry of Pd-catalyzed carbon–carbon bond-forming reactions involving allylic and propargylic compounds is outlined. Because of their special significance in organic synthesis, Pd-catalyzed asymmetric allylation and related reactions are also presented. A discussion of the synthesis of natural products via allylpalladium and related derivatives is included.