Mast cells (MCs) are a potent proangiogenic factor in tumors. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers.

Mast cells, serum tryptase and melanocytic proliferations: a clinical, pathological and serological point of view  / Paolino, Giovanni. - (2017). (Intervento presentato al convegno London Dermatopathology Symposium tenutosi a London, United Kingdom).

Mast cells, serum tryptase and melanocytic proliferations: a clinical, pathological and serological point of view 

Giovanni Paolino
2017

Abstract

Mast cells (MCs) are a potent proangiogenic factor in tumors. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1302532
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