The concept of cardiac protection, in the usual way, corresponds to any strategy of the mechanical, pharmacological, or physical types adapted to reduce or avoid the onset of cardiac permanent and disabling damage, so as to compromise the out-come. The goal is to mitigate the extent of the injury induced by the mechanism of ischemia-reperfusion and the early and late harmful effects, such as acute myocardial infarction (AMI), arrhythmias, ventricular dysfunction, cardiogenic shock, and the increase in fatal perioperative mortality. Despite advances in the understanding of what determines coronary blood fl ow, the relationship between demand and supply of oxygen, and the cellular mecha-nisms triggered by ischemia, there is still a high incidence of perioperative AMI, which varies from 3 to 30 %, in different studies
Perioperative protection of myocardial function / Tritapepe, Luigi; Carriero, Giovanni; DI PERSIO, Alessandra. - STAMPA. - (2016), pp. 165-178. [10.1007/978-3-319-31398-6_11].
Perioperative protection of myocardial function
Tritapepe, Luigi
;CARRIERO, GIOVANNI;DI PERSIO, ALESSANDRA
2016
Abstract
The concept of cardiac protection, in the usual way, corresponds to any strategy of the mechanical, pharmacological, or physical types adapted to reduce or avoid the onset of cardiac permanent and disabling damage, so as to compromise the out-come. The goal is to mitigate the extent of the injury induced by the mechanism of ischemia-reperfusion and the early and late harmful effects, such as acute myocardial infarction (AMI), arrhythmias, ventricular dysfunction, cardiogenic shock, and the increase in fatal perioperative mortality. Despite advances in the understanding of what determines coronary blood fl ow, the relationship between demand and supply of oxygen, and the cellular mecha-nisms triggered by ischemia, there is still a high incidence of perioperative AMI, which varies from 3 to 30 %, in different studiesFile | Dimensione | Formato | |
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