The intrahippocampal injection of amyloid beta peptide (1-42) (Aβ(1-42)) represents one of the most useful animal models of Alzheimer disease. Since none of these available models fully represents the main pathological hallmarks of Alzheimer disease, stereotaxic Aβ(1-42) infusion provides researchers with an in vivo alternative paradigm. When performed by well-trained individuals, this model is the best-suited one for short-term studies focusing on the effects of Aβ(1-42) on a specific brain region or circuitry. Here, we describe all methodological phases of such a model.

An animal model of Alzheimer disease based on the intrahippocampal injection of amyloid beta-peptide (Abeta) / Facchinetti, Roberta; Bronzuoli, Maria Rosanna; Scuderi, Caterina. - STAMPA. - 1727(2018), pp. 343-352. [10.1007/978-1-4939-7571-6_25].

An animal model of Alzheimer disease based on the intrahippocampal injection of amyloid beta-peptide (Abeta)

Facchinetti, Roberta;Bronzuoli, Maria Rosanna;Scuderi, Caterina
2018

Abstract

The intrahippocampal injection of amyloid beta peptide (1-42) (Aβ(1-42)) represents one of the most useful animal models of Alzheimer disease. Since none of these available models fully represents the main pathological hallmarks of Alzheimer disease, stereotaxic Aβ(1-42) infusion provides researchers with an in vivo alternative paradigm. When performed by well-trained individuals, this model is the best-suited one for short-term studies focusing on the effects of Aβ(1-42) on a specific brain region or circuitry. Here, we describe all methodological phases of such a model.
2018
Neurotrophic factors: methods and protocols
978-1-4939-7570-9
Alzheimer disease; beta-amyloid; Hippocampus; In vivo experiments; stereotaxic infusion; molecular biology; genetics
02 Pubblicazione su volume::02a Capitolo o Articolo
An animal model of Alzheimer disease based on the intrahippocampal injection of amyloid beta-peptide (Abeta) / Facchinetti, Roberta; Bronzuoli, Maria Rosanna; Scuderi, Caterina. - STAMPA. - 1727(2018), pp. 343-352. [10.1007/978-1-4939-7571-6_25].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1083492
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