In this report, we aim at presenting a viable strategy for the study of Epithelial-Mesenchymal Transition (EMT) and its opposite Mesenchymal-Epithelial Transition (MET) by means of a Systems Biology approach combined with a suitable Mathematical Modeling analysis. Precisely, it is shown how the presence of a metastable state, that is identified at a mesoscopic level of description, is crucial for making possible the appearance of a phase transition mechanism in the framework of fast-slow dynamics for Ordinary Differential Equations (ODEs).

Systems biology approach and mathematical modeling for analyzing phasespace switch during epithelial-mesenchymal transition / Simeoni, Corinne; Dinicola, S.; Cucina, A.; Mascia, C.; Bizzarri, M.. - STAMPA. - 1702(2018), pp. 95-123. [10.1007/978-1-4939-7456-6_7].

Systems biology approach and mathematical modeling for analyzing phasespace switch during epithelial-mesenchymal transition

SIMEONI, CORINNE;DINICOLA S.;CUCINA A.;MASCIA C.;BIZZARRI M.
2018

Abstract

In this report, we aim at presenting a viable strategy for the study of Epithelial-Mesenchymal Transition (EMT) and its opposite Mesenchymal-Epithelial Transition (MET) by means of a Systems Biology approach combined with a suitable Mathematical Modeling analysis. Precisely, it is shown how the presence of a metastable state, that is identified at a mesoscopic level of description, is crucial for making possible the appearance of a phase transition mechanism in the framework of fast-slow dynamics for Ordinary Differential Equations (ODEs).
2018
Systems Biology
978-1-4939-7455-9
epithelial-mesenchymal transition; mathematical modeling; mesoscopic description; metastable states; multiscale differential equations; slow-fast dynamics; stability analysis; systems biology
02 Pubblicazione su volume::02a Capitolo o Articolo
Systems biology approach and mathematical modeling for analyzing phasespace switch during epithelial-mesenchymal transition / Simeoni, Corinne; Dinicola, S.; Cucina, A.; Mascia, C.; Bizzarri, M.. - STAMPA. - 1702(2018), pp. 95-123. [10.1007/978-1-4939-7456-6_7].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1080834
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