Anthracyclines such as doxorubicin, daunorubicin, epirubicin, mitoxantrone and idarubicin, are powerful chemotherapeutic drugs used both in children and adult populations. Their properties made them particularly suitable for a large variety of neoplasms including breast adenocarcinoma, small cell lung cancer and acute leukemia. Early and late anthracycline-induced cardiotoxicity is a well-known phenomenon, and the incidence of heart failure in patients receiving doxorubicin is 2.2%, with a mortality rate over 60% at 2 years. Prognosis can be improved by prevention, early detection and treatment. A specific treatment for anthracycline-induced cardiotoxicity is not yet available, but non-pharmacological measures such as exercise, lifestyle changes and control of risk factors have shown a cardioprotective effect. Exercise training represents a viable non-pharmacological treatment as it increases cardiovascular reserve and endothelial function, regulates proapoptotic signaling, protects against reactive oxygen species (ROS), and decreases autophagy/lysosomal signaling. However, no current guidelines are available for prevention management in cancer patients. Pharmacological measures both for prevention and treatment are those used for heart failure (β-blockers, angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, statins, dexrazoxane and aldosteron antagonists). In this chapter, we will discuss how the evaluation, monitoring and prevention of chemotherapy-related cardiomyopathy is correlated with physical exercise.

The positive effects of exercise in chemotherapy-related cardiomyopathy / Cavarretta, Elena; Mastroiacovo, Giorgio; Annik, Lupieri; Frati, Giacomo; Peruzzi, Mariangela. - STAMPA. - 1000(2017), pp. 103-129. - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. [10.1007/978-981-10-4304-8_8].

The positive effects of exercise in chemotherapy-related cardiomyopathy

Elena, Cavarretta;MASTROIACOVO, GIORGIO;Giacomo, Frati;Mariangela, Peruzzi
2017

Abstract

Anthracyclines such as doxorubicin, daunorubicin, epirubicin, mitoxantrone and idarubicin, are powerful chemotherapeutic drugs used both in children and adult populations. Their properties made them particularly suitable for a large variety of neoplasms including breast adenocarcinoma, small cell lung cancer and acute leukemia. Early and late anthracycline-induced cardiotoxicity is a well-known phenomenon, and the incidence of heart failure in patients receiving doxorubicin is 2.2%, with a mortality rate over 60% at 2 years. Prognosis can be improved by prevention, early detection and treatment. A specific treatment for anthracycline-induced cardiotoxicity is not yet available, but non-pharmacological measures such as exercise, lifestyle changes and control of risk factors have shown a cardioprotective effect. Exercise training represents a viable non-pharmacological treatment as it increases cardiovascular reserve and endothelial function, regulates proapoptotic signaling, protects against reactive oxygen species (ROS), and decreases autophagy/lysosomal signaling. However, no current guidelines are available for prevention management in cancer patients. Pharmacological measures both for prevention and treatment are those used for heart failure (β-blockers, angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, statins, dexrazoxane and aldosteron antagonists). In this chapter, we will discuss how the evaluation, monitoring and prevention of chemotherapy-related cardiomyopathy is correlated with physical exercise.
2017
Exercise for Cardiovascular Disease Prevention and Treatment
978-981-10-4303-1
978-981-10-4304-8
anthracycline; cardiotoxicity; chemotherapy-related cardiomyopathy; exercise; prevention; biochemistry, genetics and molecular biology (all)
02 Pubblicazione su volume::02a Capitolo o Articolo
The positive effects of exercise in chemotherapy-related cardiomyopathy / Cavarretta, Elena; Mastroiacovo, Giorgio; Annik, Lupieri; Frati, Giacomo; Peruzzi, Mariangela. - STAMPA. - 1000(2017), pp. 103-129. - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. [10.1007/978-981-10-4304-8_8].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1023646
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