AT1R-AT2R Cross Talk

In vitro and in vivo studies have shown that angiotensin II type 1 receptor (AT1R) stimulation may regulate the expression of angiotensin II type 2 receptor (AT2R), suggesting the existence of a complex cross regulatory mechanism between the two subtype receptors. In the vasculature, a negative cross talk between AT2R and AT1R may also occur in terms of reduced AT1R expression and signaling in the presence of AT2R stimulation and/or overexpression. Finally, a functional counterregulatory mechanism among angiotensin II (Ang II) subtype receptors and growth-promoting receptors may occur at the expression and signaling level. This might contribute to the modulation of the Ang II-induced damage in the cardiovascular system