Although the progression in diagnostic tools, prevention strategies, and therapies, ischemic heart disease still represents the major cause of mortality and morbidity worldwide that globally represents an important problem for individuals and healthcare resources. By convention, ischemic heart disease is associated with the presence of an atherosclerotic plaque that is able to limit the flow in large-medium-sized coronary arteries. Nevertheless, several findings suggest a more complex pathophysiology of ischemic heart disease. At this time, there is no well-defined assessment of myocardial ischemia pathophysiology. Moreover, several data have identified genetic variations at different loci that are linked with ischemic heart disease susceptibility. This chapter aims to examine this complicated disease and to review the evidence on the genetic heritability acting with other factors in determining the presence of ischemic heart disease, due to either an obstruction in epicardial vessels or a dysfunction of coronary microcirculation

Genetic polymorphisms and ischemic heart disease / Fedele, Francesco; Pucci, Mariateresa; Severino, Paolo. - STAMPA. - (2017), pp. 205-219. [10.5772/intechopen.69621].

Genetic polymorphisms and ischemic heart disease

Francesco Fedele
Primo
Writing – Review & Editing
;
PUCCI, MARIATERESA
Secondo
Writing – Original Draft Preparation
;
Paolo Severino
Ultimo
Writing – Original Draft Preparation
2017

Abstract

Although the progression in diagnostic tools, prevention strategies, and therapies, ischemic heart disease still represents the major cause of mortality and morbidity worldwide that globally represents an important problem for individuals and healthcare resources. By convention, ischemic heart disease is associated with the presence of an atherosclerotic plaque that is able to limit the flow in large-medium-sized coronary arteries. Nevertheless, several findings suggest a more complex pathophysiology of ischemic heart disease. At this time, there is no well-defined assessment of myocardial ischemia pathophysiology. Moreover, several data have identified genetic variations at different loci that are linked with ischemic heart disease susceptibility. This chapter aims to examine this complicated disease and to review the evidence on the genetic heritability acting with other factors in determining the presence of ischemic heart disease, due to either an obstruction in epicardial vessels or a dysfunction of coronary microcirculation
2017
Genetic Polymorphisms
9789535135166
9789535135159
genetic polymorphisms; ischemic heart disease; risk factors
02 Pubblicazione su volume::02a Capitolo o Articolo
Genetic polymorphisms and ischemic heart disease / Fedele, Francesco; Pucci, Mariateresa; Severino, Paolo. - STAMPA. - (2017), pp. 205-219. [10.5772/intechopen.69621].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1015638
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