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Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome, file e3835325-4385-15e8-e053-a505fe0a3de9
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185
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Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome, file e383531e-029b-15e8-e053-a505fe0a3de9
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151
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Down syndrome Is a metabolic disease: altered Insulin signaling mediates peripheral and brain dysfunctions, file e3835327-5270-15e8-e053-a505fe0a3de9
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129
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Heme oxygenase-1 in central nervous system malignancies, file e3835326-d1fd-15e8-e053-a505fe0a3de9
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111
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It is all about (U)biquitin: role of altered ubiquitin-proteasome system and UCHL1 in Alzheimer disease, file e3835319-c612-15e8-e053-a505fe0a3de9
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66
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Proteomics study of peripheral blood mononuclear cells in down syndrome children, file e383532b-f00a-15e8-e053-a505fe0a3de9
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61
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Activation of p53 in down syndrome and in the ts65dn mouse brain is associated with a pro-apoptotic phenotype, file e383532b-8c3f-15e8-e053-a505fe0a3de9
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60
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Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease, file e3835327-e29b-15e8-e053-a505fe0a3de9
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58
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Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome, file e383532a-b97a-15e8-e053-a505fe0a3de9
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55
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The BACH1/Nrf2 axis in brain in down syndrome and transition to alzheimer disease-like neuropathology and dementia, file e3835328-66e9-15e8-e053-a505fe0a3de9
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51
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BVR-A deficiency leads to autophagy impairment through the dysregulation of AMPK/mTOR axis in the brain—Implications for neurodegeneration, file e3835329-2fd8-15e8-e053-a505fe0a3de9
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49
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Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimer’s disease-like neuropathology in a mouse model for Down syndrome, file 990cec48-fd40-462c-a54f-f20c698674e4
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48
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Bach1 overexpression in down syndrome correlates with the alteration of the ho-1/bvr-a system: insights for transition to Alzheimer's disease, file e383531b-777e-15e8-e053-a505fe0a3de9
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48
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Reduced biliverdin reductase-a expression in visceral adipose tissue is associated with adipocyte dysfunction and nafld in human obesity, file e3835329-25da-15e8-e053-a505fe0a3de9
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47
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Brain insulin resistance: An early risk factor for Alzheimer's disease development in down syndrome, file e383532e-3c27-15e8-e053-a505fe0a3de9
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31
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High-fat diet leads to reduced protein o-glcnacylation and mitochondrial defects promoting the development of Alzheimer’s disease signatures, file 5aa4a0c5-281a-4692-b339-c8755129c97e
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27
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Building the future therapies for down syndrome: the third international conference of the T21 research society, file e383532d-f792-15e8-e053-a505fe0a3de9
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25
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Role of biliverdin reductase A in the regulation of insulin signaling in metabolic and neurodegenerative diseases: An update, file 53cbea42-e840-4b88-b625-78cc8cf9f07b
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21
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Valorization of tomato waste as a source of carotenoids, file e383532e-2f42-15e8-e053-a505fe0a3de9
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17
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Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles, file 9b174a8b-c9e0-4fa0-aae2-01324e8457b5
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15
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Editorial: Brain insulin resistance in neurodevelopmental and neurodegenerative disorders: mind the gap!, file e383532e-4f8a-15e8-e053-a505fe0a3de9
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15
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A bioengineering strategy to control ADAM10 activity in living cells, file 731296dd-2d14-43e8-8d69-98ce5e6fcdcf
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12
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Dynamic changes of BVRA protein levels occur in response to insulin: a pilot study in humans, file 1be323c6-fbfb-497f-876a-19f0ef46bb81
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10
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HO-1/BVR-A system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: A potential biochemical marker for the prediction of the disease, file e3835311-a567-15e8-e053-a505fe0a3de9
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8
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The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease, file e383532e-3f33-15e8-e053-a505fe0a3de9
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5
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Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control, file e383532e-9f00-15e8-e053-a505fe0a3de9
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5
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Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling, file e383532f-1659-15e8-e053-a505fe0a3de9
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5
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Engineering memory with an extrinsically disordered kinase, file 1dbd08b1-efb0-4564-8716-1af65f67d9e8
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4
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Borsa miglior poster, file e3835324-9005-15e8-e053-a505fe0a3de9
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4
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mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder, file e383532e-40d9-15e8-e053-a505fe0a3de9
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4
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Aberrant protein networks in Alzheimer disease, file e383532f-0b73-15e8-e053-a505fe0a3de9
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4
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Strategy to reduce free radical species in Alzheimer's disease: an update of selected antioxidants, file e3835312-52bf-15e8-e053-a505fe0a3de9
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3
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Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53, file e3835312-d933-15e8-e053-a505fe0a3de9
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3
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Increased mammalian target of rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of down's syndrome, file e3835313-e4bf-15e8-e053-a505fe0a3de9
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3
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Impairment of biliverdin reductase-a promotes brain insulin resistance in Alzheimer disease: a new paradigm, file e3835314-176d-15e8-e053-a505fe0a3de9
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3
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Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways, file e3835319-bfe1-15e8-e053-a505fe0a3de9
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3
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Early and selective activation and subsequent alterations to the unfolded protein response in down syndrome mouse models, file e383531a-045f-15e8-e053-a505fe0a3de9
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3
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Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: implications for Alzheimer disease, file e383531d-5991-15e8-e053-a505fe0a3de9
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3
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HNE-modified proteins in Down syndrome: involvement in development of Alzheimer disease neuropathology, file e383531d-5994-15e8-e053-a505fe0a3de9
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3
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Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: novel hints on immunosenescence and biomarker detection, file e383531d-7d02-15e8-e053-a505fe0a3de9
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3
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Editorial: Oxidative stress and Alzheimer disease: where do we stand?, file e3835329-b867-15e8-e053-a505fe0a3de9
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3
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Neuropathological role of pi3k/akt/mtor axis in Down syndrome brain, file e3835311-d7fb-15e8-e053-a505fe0a3de9
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2
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Poly-ubiquitin profile in Alzheimer disease brain, file e383531d-2ac6-15e8-e053-a505fe0a3de9
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2
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Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease, file e3835320-55a6-15e8-e053-a505fe0a3de9
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2
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Chronic perk induction promotes alzheimer-like neuropathology in down syndrome: Insights for therapeutic intervention, file 63147f27-e4f6-4213-a964-8c658b4f18b1
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1
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Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action, file e3835311-dcb5-15e8-e053-a505fe0a3de9
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1
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Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion., file e3835312-05d6-15e8-e053-a505fe0a3de9
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1
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In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig, file e3835319-b119-15e8-e053-a505fe0a3de9
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1
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The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation, file e383531a-28dd-15e8-e053-a505fe0a3de9
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1
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Disturbance of redox homeostasis in down syndrome: role of iron dysmetabolism, file e383531a-8b5b-15e8-e053-a505fe0a3de9
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1
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Polyubiquitinylation profile in down syndrome brain before and after the development of Alzheimer neuropathology, file e3835321-29f9-15e8-e053-a505fe0a3de9
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1
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Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus, file e3835323-bd7a-15e8-e053-a505fe0a3de9
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1
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Behavioural and neuropathological effects of intranasal insulin treatment in a triple-transgenic mouse model of Alzheimer's disease (3xTg-AD), file e3835324-6612-15e8-e053-a505fe0a3de9
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1
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Curcumin and alzheimer disease: this marriage is not to be performed, file e3835325-928d-15e8-e053-a505fe0a3de9
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1
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Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome, file e3835329-5874-15e8-e053-a505fe0a3de9
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1
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CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome, file e383532f-3bde-15e8-e053-a505fe0a3de9
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1
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Insulin Signaling Regulates Mitochondrial Bioenergetics in the Brain: Insight for the Development of Neurodegenerative Diseases, file e6ceeba4-c46f-4072-81be-1803772cfd25
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1
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| Totale |
1.380 |