FIORILLO, ANNARITA

FIORILLO, ANNARITA  

DIPARTIMENTO DI SCIENZE BIOCHIMICHE "ALESSANDRO ROSSI FANELLI"  

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A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition. 2012 Ilari, Andrea; Baiocco, P; Messori, L; Fiorillo, Annarita; Boffi, Alberto; Gramiccia, M; Di Muccio, T; Colotti, G.
An update on structural insights into the enzymes of the polyamine-trypanothione pathway: Targets for new drugs against leishmaniasis 2017 Ilari, Andrea; Fiorillo, Annarita; Genovese, Ilaria; Colotti, Gianni
Binding of doxorubicin to sorcin impairs cell death and increases drug resistance in cancer cells 2017 Genovese, Ilaria; Fiorillo, Annarita; Ilari, Andrea; Masciarelli, Silvia; Fazi, Francesco; Colotti, Gianni
Crystal structure of a family 16 endoglucanase from the hyperthermophile Pyrococcus furiosus- structural basis of substrate recognition. 2009 Ilari, Andrea; Fiorillo, A; Angelaccio, Sebastiana; Florio, Rita; Chiaraluce, Roberta; VAN DER OOST, J; Consalvi, Valerio
Crystallization and preliminary X-ray crystallographic analysis of the laminarinase endo-beta-1,3-glucanase from Pyrococcus furiosus. 2004 Ilari, Andrea; Angelaccio, Sebastiana; Fiorillo, Annarita; Florio, Rita; Consalvi, Valerio; Chiaraluce, Roberta
Fragment merging, growing, and linking identify new trypanothione reductase inhibitors for Leishmaniasis 2024 Exertier, Cécile; Salerno, Alessandra; Antonelli, Lorenzo; Fiorillo, Annarita; Ocello, Riccardo; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Masetti, Matteo; Fiorentino, Eleonora; Orsini, Stefania; Di Muccio, Trentina; Ilari, Andrea; Bolognesi, Maria Laura
Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure? 2017 Morea, Veronica; Bidollari, Eris; Colotti, Gianni; Fiorillo, Annarita; Rosati, Jessica Diana; De Filippis, Lidia; Squitieri, Ferdinando; Ilari, Andrea
Huntingtin ubiquitination mechanisms and novel possible therapies to decrease the toxic effects of mutated huntingtin 2021 Fiorillo, A.; Morea, V.; Colotti, G.; Ilari, A.
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase 2021 Barile, Anna; Battista, Theo; Fiorillo, Annarita; Luigi di Salvo, Martino; Malatesta, Francesco; Tramonti, Angela; Ilari, Andrea; Contestabile, Roberto
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase 2024 Barile, Anna; Graziani, Claudio; Antonelli, Lorenzo; Parroni, Alessia; Fiorillo, Annarita; di Salvo, Martino Luigi; Ilari, Andrea; Giorgi, Alessandra; Rosignoli, Serena; Paiardini, Alessandro; Contestabile, Roberto; Tramonti, Angela
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography 2013 Baiocco, P.; Poce, Giovanna; Alfonso, Salvatore; Cocozza, Martina; Porretta, Giulio Cesare; Colotti, G.; Biava, Mariangela; Moraca, F.; Botta, M.; Yardley, V.; Fiorillo, A.; Lantella, A.; Malatesta, Francesco; Ilari, Andrea
Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives 2017 Saccoliti, Francesco; Angiulli, Gabriella; Pupo, Giovanni; Pescatori, Luca; Madia, VALENTINA NOEMI; Messore, Antonella; Colotti, Gianni; Fiorillo, Annarita; Scipione, Luigi; Gramiccia, Marina; Di Muccio, Trentina; DI SANTO, Roberto; Costi, Roberta; Ilari, Andrea
Inhibition of Leishmania infantum trypanothione reductase by NADPH, its natural substrate 2012 Lantella, Antonella; Giorgi, Alessandra; Baiocco, Paola; Fiorillo, Annarita; Schinina', Maria Eugenia; G., Colotti; Ilari, Andrea; Malatesta, Francesco
Innovative approach for a classic target: fragment screening on trypanothione reductase reveals new opportunities for drug design 2022 Fiorillo, A; Colotti, G; Exertier, C; Liuzzi, A; Seghetti, F; Salerno, A; Caciolla, J; Ilari, Andrea
Investigation of the entry pathway and molecular nature of σ1 receptor ligands 2023 Pascarella, Gianmarco; Antonelli, Lorenzo; Narzi, Daniele; Battista, Theo; Fiorillo, Annarita; Colotti, Gianni; Guidoni, Leonardo; Morea, Veronica; Ilari, Andrea
Kineococcus radiotolerans Dps forms a heteronuclear Mn-Fe ferroxidase center that may explain the Mn-dependent protection against oxidative stress 2013 Ardini, Matteo; Fiorillo, Annarita; Fittipaldi, Maria; Stefanini, Simonetta; Gatteschi, Dante; Ilari, Andrea; Chiancone, Emilia
Known drugs identified by structure-based virtual screening are able to bind sigma-1 receptor and increase growth of huntington disease patient-derived cells 2021 Battista, T.; Pascarella, G.; Staid, D. S.; Colotti, G.; Rosati, J.; Fiorillo, A.; Casamassa, A.; Vescovi, A. L.; Giabbai, B.; Semrau, M. S.; Fanelli, S.; Storici, P.; Squitieri, F.; Morea, V.; Ilari, A.
Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases 2018 Colotti, Gianni; Fiorillo, Annarita; Ilari, Andrea
Metal-based compounds as prospective antileishmanial agents: Inhibition of Trypanothione reductase by selected gold complexes 2013 Colotti, Gianni; Ilari, Andrea; Fiorillo, Annarita; Baiocco, Paola; Cinellu, Maria Agostina; Maiore, Laura; Scaletti, Federica; Gabbiani, Chiara; Messori, Luigi
Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents 2018 Genovese, Ilaria; Ilari, Andrea; Battista, Theo; Chiarini, Valerio; Fazi, Francesco; Fiorillo, Annarita; Colotti, Gianni