| Nome |
# |
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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer, file e3835314-1399-15e8-e053-a505fe0a3de9
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369
|
|
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b, file e3835320-fa98-15e8-e053-a505fe0a3de9
|
242
|
|
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835321-b62e-15e8-e053-a505fe0a3de9
|
163
|
|
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities, file e3835318-8dce-15e8-e053-a505fe0a3de9
|
155
|
|
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules, file e3835316-c0e6-15e8-e053-a505fe0a3de9
|
113
|
|
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy, file e383531a-82b0-15e8-e053-a505fe0a3de9
|
100
|
|
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses, file e3835315-5afb-15e8-e053-a505fe0a3de9
|
89
|
|
Targeting the interaction between the SH3 domain of Grb2 and Gab2, file e3835328-65a3-15e8-e053-a505fe0a3de9
|
79
|
|
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics, file e3835327-af36-15e8-e053-a505fe0a3de9
|
68
|
|
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage, file e3835329-2cf4-15e8-e053-a505fe0a3de9
|
61
|
|
Indolyl Aryl Sulfones, HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Docking and 3-D QSAR studies, file e3835319-0dc8-15e8-e053-a505fe0a3de9
|
60
|
|
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group, file e3835327-c078-15e8-e053-a505fe0a3de9
|
51
|
|
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor, file e383532e-2da4-15e8-e053-a505fe0a3de9
|
49
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Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites, file e3835328-4581-15e8-e053-a505fe0a3de9
|
45
|
|
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer, file e383532d-208c-15e8-e053-a505fe0a3de9
|
29
|
|
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment, file 8731833a-0256-4952-840b-6835a6e85c87
|
23
|
|
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent, file e481c586-3297-49db-842a-3459cd8a4226
|
19
|
|
Exploring CCRL2 chemerin binding using accelerated molecular dynamics, file e383532e-d534-15e8-e053-a505fe0a3de9
|
18
|
|
Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors, file e3835311-fdbb-15e8-e053-a505fe0a3de9
|
17
|
|
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin, file e3835318-86c8-15e8-e053-a505fe0a3de9
|
17
|
|
Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors, file e3835322-0cb8-15e8-e053-a505fe0a3de9
|
14
|
|
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells, file 627e2e0f-3a39-4d2c-8fef-60960843e574
|
12
|
|
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group, file e3835327-c079-15e8-e053-a505fe0a3de9
|
10
|
|
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin, file e383531d-e9b0-15e8-e053-a505fe0a3de9
|
8
|
|
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2, file e3835312-5cda-15e8-e053-a505fe0a3de9
|
6
|
|
New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation, file e3835315-f178-15e8-e053-a505fe0a3de9
|
6
|
|
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors, file e3835314-16e9-15e8-e053-a505fe0a3de9
|
5
|
|
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors, file e383531a-dcc3-15e8-e053-a505fe0a3de9
|
4
|
|
Inhibition of dengue virus by novel inhibitors of RNA-dependent RNA polymerase and protease activity, file e3835322-2c00-15e8-e053-a505fe0a3de9
|
4
|
|
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor, file 14ddf683-85fe-4882-b5d4-bbfe6c5e2deb
|
3
|
|
Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection, file d677836c-b1be-49fc-b71e-6e6343267c90
|
3
|
|
Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase, file e3835315-45ba-15e8-e053-a505fe0a3de9
|
3
|
|
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies, file e3835322-06e7-15e8-e053-a505fe0a3de9
|
3
|
|
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress, file e3835323-f22a-15e8-e053-a505fe0a3de9
|
3
|
|
Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc, file e3835329-2cfb-15e8-e053-a505fe0a3de9
|
3
|
|
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia, file e383532c-7033-15e8-e053-a505fe0a3de9
|
3
|
|
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators, file a1266567-afef-4c80-bd57-7b2f43f0a90f
|
2
|
|
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents, file e3835312-6c9a-15e8-e053-a505fe0a3de9
|
2
|
|
An in-silico approach aimed to clarify the role of Y181C and K103N HIV-1 reverse transcriptase mutations versus Indole Aryl Sulphones, file e3835315-779a-15e8-e053-a505fe0a3de9
|
2
|
|
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer, file e3835316-c9b9-15e8-e053-a505fe0a3de9
|
2
|
|
Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents, file e3835318-c9cd-15e8-e053-a505fe0a3de9
|
2
|
|
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication, file e383531d-365f-15e8-e053-a505fe0a3de9
|
2
|
|
Small molecule inhibitors of kdm5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B, file e3835324-0248-15e8-e053-a505fe0a3de9
|
2
|
|
Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835324-0461-15e8-e053-a505fe0a3de9
|
2
|
|
The tubulin colchicine domain: a molecular modelling perspective., file e3835311-d499-15e8-e053-a505fe0a3de9
|
1
|
|
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis., file e3835311-d49e-15e8-e053-a505fe0a3de9
|
1
|
|
De novo computer-aided design of novel antiviral agents., file e3835312-4cc6-15e8-e053-a505fe0a3de9
|
1
|
|
VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection, file e3835315-a1af-15e8-e053-a505fe0a3de9
|
1
|
|
Structural biology in antiviral drug discovery, file e3835315-aadd-15e8-e053-a505fe0a3de9
|
1
|
|
3-Aroyl-1-arylpyrroles as new anticancer agents, file e3835317-0a11-15e8-e053-a505fe0a3de9
|
1
|
|
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study, file e3835318-bc7e-15e8-e053-a505fe0a3de9
|
1
|
|
Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis, file e3835318-ccc7-15e8-e053-a505fe0a3de9
|
1
|
|
Towards modern anticancer agents that interact with tubulin, file e3835321-5b61-15e8-e053-a505fe0a3de9
|
1
|
|
First in class pdz1 targeting NHERF1 inhibitors as anticancer agents, file e3835321-6e15-15e8-e053-a505fe0a3de9
|
1
|
|
Treating chronic myeloid leukemia by inhibition of tubulin polymerization, file e3835321-b769-15e8-e053-a505fe0a3de9
|
1
|
|
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin, file e3835321-f7c7-15e8-e053-a505fe0a3de9
|
1
|
|
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies, file e3835323-f9c0-15e8-e053-a505fe0a3de9
|
1
|
|
Evaluation of pharmacophoric models at colchicine binding site by ROC curves, file e3835324-1543-15e8-e053-a505fe0a3de9
|
1
|
|
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains, file e3835327-9f87-15e8-e053-a505fe0a3de9
|
1
|
| Totale |
1.888 |